Relationship between maternal and neonatal levels of antibodies to 48 kDa SSB(La), 52 kDa SSA(Ro), and 60 kDa SSA(Ro) in pregnancies complicated by congenital heart block.
Buyon J, Waltuck J, Caldwell K, Crawford B, Slade S, Copel J, Chan E. Relationship between maternal and neonatal levels of antibodies to 48 kDa SSB(La), 52 kDa SSA(Ro), and 60 kDa SSA(Ro) in pregnancies complicated by congenital heart block. The Journal Of Rheumatology 1994, 21: 1943-50. PMID: 7837164.Peer-Reviewed Original ResearchConceptsCongenital heart blockAnti-60Heart blockCirculation of neonatesRatios of maternalUmbilical cord levelsTotal IgG levelsMean ratioAnti-52Neonatal circulationCord levelIgG levelsMaternal antibodiesSerum levelsNeonatal levelsUnaffected pregnanciesControl groupPregnancyFetal tissuesSelective depletionAntibodiesAutoantibodiesIndirect evidenceGroupNeonates