Enhanced Conversion of Racemic α-Arylalanines to (R)-β-Arylalanines by Coupled Racemase/Aminomutase Catalysis
Cox B, Bilsborrow J, Walker K. Enhanced Conversion of Racemic α-Arylalanines to (R)-β-Arylalanines by Coupled Racemase/Aminomutase Catalysis. The Journal Of Organic Chemistry 2009, 74: 6953-6959. PMID: 19711925, DOI: 10.1021/jo9009563.Peer-Reviewed Original ResearchMeSH KeywordsAlanineBenzene DerivativesBinding SitesBiocatalysisPhenylalanine Ammonia-LyasePseudomonas putidaRacemases and EpimerasesStereoisomerismTaxusConceptsPhenylalanine aminomutaseRacemic starting materialsOverall reaction yieldBiocatalytic racemizationRacemic substratesReaction mixtureProduction of enantiopureAminomutase reactionBuilding blocksAlanine racemaseCatalysisPseudomonas putidaReactionReaction fluxesEnhanced conversionAminomutaseEnantiopureRacemizationSubstrateDegrees CKT2440