Poxviral vectors for cancer immunotherapy
Kim JW, Gulley JL. Poxviral vectors for cancer immunotherapy. Expert Opinion On Biological Therapy 2012, 12: 463-478. PMID: 22413824, PMCID: PMC3482162, DOI: 10.1517/14712598.2012.668516.Peer-Reviewed Original ResearchConceptsAppropriate patient selectionClinical trial designPatient selectionTrial designMetastatic castration-resistant prostate cancerPlacebo-controlled clinical trialCastration-resistant prostate cancerNovel immunologic approachesPhase III randomizedScience of immunotherapyImmune-based therapiesMultiple costimulatory moleculesTumor-associated antigensEarly clinical studiesAppropriate end pointsPoxviral vaccinesPSA-TRICOMHormonal therapyNovel immunotherapiesPoxviral vectorsCancer vaccinesCostimulatory moleculesCancer immunotherapyTreatment modalitiesImmunologic approaches