2024
Lower Microscopy Sensitivity with Decreasing Malaria Prevalence in the Urban Amazon Region, Brazil, 2018–2021 - Volume 30, Number 9—September 2024 - Emerging Infectious Diseases journal - CDC
Rodrigues P, Johansen I, Ladeia W, Esquivel F, Corder R, Tonini J, Calil P, Fernandes A, Fontoura P, Cavasini C, Vinetz J, Castro M, Ferreira M, . Lower Microscopy Sensitivity with Decreasing Malaria Prevalence in the Urban Amazon Region, Brazil, 2018–2021 - Volume 30, Number 9—September 2024 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2024, 30: 1884-1894. PMID: 39174028, PMCID: PMC11346994, DOI: 10.3201/eid3009.240378.Peer-Reviewed Original ResearchConceptsEffectiveness of malaria controlDecreasing malaria prevalenceEpidemiology of malariaPoint-of-care microscopyThreshold of microscopyPlasmodium vivaxMalaria prevalenceMalarial infectionMalaria controlMalaria transmissionP. falciparumMicroscopy sensitivityParasite densityAsymptomatic infectionRoutine surveillanceMalariaPrevalence surveyInfectionPrevalenceParasite genotypesTransmission hotspotsElimination strategiesRural residentsMolecular methodsCDCGenomic surveillance of malaria parasites in an indigenous community in the Peruvian Amazon
Cabrera-Sosa L, Nolasco O, Kattenberg J, Fernandez-Miñope C, Valdivia H, Barazorda K, Arévalo de los Rios S, Rodriguez-Ferrucci H, Vinetz J, Rosanas-Urgell A, Van geertruyden J, Gamboa D, Delgado-Ratto C. Genomic surveillance of malaria parasites in an indigenous community in the Peruvian Amazon. Scientific Reports 2024, 14: 16291. PMID: 39009685, PMCID: PMC11250820, DOI: 10.1038/s41598-024-66925-x.Peer-Reviewed Original ResearchConceptsPassive case detectionPf parasitesPersistent malaria transmissionPfhrp2/3 gene deletionsDeep sequencing assaySulfadoxine-pyrimethamineMalaria casesMalaria eliminationPlasmodium vivaxMalaria parasitesMalaria transmissionP. falciparumResistance mutationsImported infectionsMalariaPopulation genetic indicesSequencing assayCase detectionGene deletionPV populationResistance markersGenetic diversityPeruvian AmazonGenomic surveillanceGenetic indices
2021
Optimizing the microscopic agglutination test (MAT) panel for the diagnosis of Leptospirosis in a low resource, hyper-endemic setting with varied microgeographic variation in reactivity
Jayasundara D, Gamage C, Senavirathna I, Warnasekara J, Matthias MA, Vinetz J, Agampodi S. Optimizing the microscopic agglutination test (MAT) panel for the diagnosis of Leptospirosis in a low resource, hyper-endemic setting with varied microgeographic variation in reactivity. PLOS Neglected Tropical Diseases 2021, 15: e0009565. PMID: 34197457, PMCID: PMC8279374, DOI: 10.1371/journal.pntd.0009565.Peer-Reviewed Original Research
2018
Acceptability of a herd immunity-focused, transmission-blocking malaria vaccine in malaria-endemic communities in the Peruvian Amazon: an exploratory study
White SE, Harvey SA, Meza G, Llanos A, Guzman M, Gamboa D, Vinetz JM. Acceptability of a herd immunity-focused, transmission-blocking malaria vaccine in malaria-endemic communities in the Peruvian Amazon: an exploratory study. Malaria Journal 2018, 17: 179. PMID: 29703192, PMCID: PMC5921293, DOI: 10.1186/s12936-018-2328-z.Peer-Reviewed Original ResearchConceptsTransmission-blocking malaria vaccineTransmission-blocking vaccinesMalaria vaccineMalaria transmission-blocking vaccineMalaria hypoendemic regionMalaria vaccine strategyProspective cohort studyMalaria-endemic communitiesMalaria-endemic regionsPre-validated questionnaireCohort studyVaccine strategiesMalaria infectionMethodsThe studyVaccineMalaria controlMalaria researchMultiple injectionsOne-thirdIndustrialized worldInjectionAcceptabilityCohortInfectionStudy
2016
Reactive Case Detection for Plasmodium vivax Malaria Elimination in Rural Amazonia
Fontoura PS, Finco BF, Lima NF, de Carvalho JF, Vinetz JM, Castro MC, Ferreira MU. Reactive Case Detection for Plasmodium vivax Malaria Elimination in Rural Amazonia. PLOS Neglected Tropical Diseases 2016, 10: e0005221. PMID: 27941968, PMCID: PMC5179126, DOI: 10.1371/journal.pntd.0005221.Peer-Reviewed Original ResearchConceptsMalaria eliminationIndex caseElimination effortsControl householdsCorrelates of infectionReactive case detectionMixed-effects logistic regression modelResidual malaria transmissionCase detection strategiesMolecular genotypingMalaria elimination effortsP. vivax transmissionTotal parasite biomassReal-time polymerase chain reactionQuantitative real-time polymerase chain reactionLogistic regression modelsP. vivax diversityPotential confoundersAsymptomatic carriersPolymerase chain reactionCase detectionIndex householdsQPCR-positive samplesMalaria burdenPlasmodium vivax