Reactive Case Detection for Plasmodium vivax Malaria Elimination in Rural Amazonia
Fontoura PS, Finco BF, Lima NF, de Carvalho JF, Vinetz JM, Castro MC, Ferreira MU. Reactive Case Detection for Plasmodium vivax Malaria Elimination in Rural Amazonia. PLOS Neglected Tropical Diseases 2016, 10: e0005221. PMID: 27941968, PMCID: PMC5179126, DOI: 10.1371/journal.pntd.0005221.Peer-Reviewed Original ResearchConceptsMalaria eliminationIndex caseElimination effortsControl householdsCorrelates of infectionReactive case detectionMixed-effects logistic regression modelResidual malaria transmissionCase detection strategiesMolecular genotypingMalaria elimination effortsP. vivax transmissionTotal parasite biomassReal-time polymerase chain reactionQuantitative real-time polymerase chain reactionLogistic regression modelsP. vivax diversityPotential confoundersAsymptomatic carriersPolymerase chain reactionCase detectionIndex householdsQPCR-positive samplesMalaria burdenPlasmodium vivax