2024
Lower Microscopy Sensitivity with Decreasing Malaria Prevalence in the Urban Amazon Region, Brazil, 2018–2021 - Volume 30, Number 9—September 2024 - Emerging Infectious Diseases journal - CDC
Rodrigues P, Johansen I, Ladeia W, Esquivel F, Corder R, Tonini J, Calil P, Fernandes A, Fontoura P, Cavasini C, Vinetz J, Castro M, Ferreira M, . Lower Microscopy Sensitivity with Decreasing Malaria Prevalence in the Urban Amazon Region, Brazil, 2018–2021 - Volume 30, Number 9—September 2024 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2024, 30: 1884-1894. PMID: 39174028, PMCID: PMC11346994, DOI: 10.3201/eid3009.240378.Peer-Reviewed Original ResearchConceptsEffectiveness of malaria controlDecreasing malaria prevalenceEpidemiology of malariaPoint-of-care microscopyThreshold of microscopyPlasmodium vivaxMalaria prevalenceMalarial infectionMalaria controlMalaria transmissionP. falciparumMicroscopy sensitivityParasite densityAsymptomatic infectionRoutine surveillanceMalariaPrevalence surveyInfectionPrevalenceParasite genotypesTransmission hotspotsElimination strategiesRural residentsMolecular methodsCDCEvaluation of combination vaccines targeting transmission of Plasmodium falciparum and P. vivax
Cao Y, Hayashi C, Araujo M, Tripathi A, Andrade A, Medeiros J, Vinetz J, Kumar N. Evaluation of combination vaccines targeting transmission of Plasmodium falciparum and P. vivax. Vaccine 2024, 42: 126140. PMID: 39033079, PMCID: PMC11338703, DOI: 10.1016/j.vaccine.2024.07.041.Peer-Reviewed Original ResearchDirect membrane feeding assaysTransmission-reducing activityStandard membrane feeding assayMembrane feeding assaysP. vivaxDNA vaccineP. falciparumPlasmodium falciparumTransmission of Plasmodium falciparumAntibody responseDNA vaccine platformP. vivax accountsGlobal malaria burdenTransmission-blocking activityTransmission of malariaCombination of DNA vaccineIn vivo electroporationCombined DNA vaccineMalaria burdenMalaria transmissionTransmission-blockingAssess immunogenicityVaccine platformClinical studiesCombination groupGenomic surveillance of malaria parasites in an indigenous community in the Peruvian Amazon
Cabrera-Sosa L, Nolasco O, Kattenberg J, Fernandez-Miñope C, Valdivia H, Barazorda K, Arévalo de los Rios S, Rodriguez-Ferrucci H, Vinetz J, Rosanas-Urgell A, Van geertruyden J, Gamboa D, Delgado-Ratto C. Genomic surveillance of malaria parasites in an indigenous community in the Peruvian Amazon. Scientific Reports 2024, 14: 16291. PMID: 39009685, PMCID: PMC11250820, DOI: 10.1038/s41598-024-66925-x.Peer-Reviewed Original ResearchConceptsPassive case detectionPf parasitesPersistent malaria transmissionPfhrp2/3 gene deletionsDeep sequencing assaySulfadoxine-pyrimethamineMalaria casesMalaria eliminationPlasmodium vivaxMalaria parasitesMalaria transmissionP. falciparumResistance mutationsImported infectionsMalariaPopulation genetic indicesSequencing assayCase detectionGene deletionPV populationResistance markersGenetic diversityPeruvian AmazonGenomic surveillanceGenetic indicesEffect of spatiotemporal variables on abundance, biting activity and parity of Nyssorhynchus darlingi (Diptera: Culicidae) in peri-Iquitos, Peru
Bickersmith S, Saavedra M, Prussing C, Lange R, Morales J, Alava F, Vinetz J, Gamboa D, Moreno M, Conn J. Effect of spatiotemporal variables on abundance, biting activity and parity of Nyssorhynchus darlingi (Diptera: Culicidae) in peri-Iquitos, Peru. Malaria Journal 2024, 23: 112. PMID: 38641572, PMCID: PMC11031940, DOI: 10.1186/s12936-024-04940-z.Peer-Reviewed Original ResearchConceptsMalaria transmissionBreeding site availabilityPresence of Plasmodium vivaxDry seasonBiting behaviorRisk of malaria transmissionMalaria-endemic regionsHuman malaria casesPlasmodium falciparum sporozoitesRainy seasonCommunity typesNyssorhynchus darlingiRates of parityReal-time PCRAmazonian PeruP. vivaxMalaria casesPlasmodium vivaxHuman landing catchesP. falciparumEffect of seasonMosquito behaviorConclusionsThese dataDaily survivalDarlingi
2016
Evaluation of monoclonal antibodies against pfMSP10 for the prospective use on in vitro growth inhibition assays of peruvian P. falciparum isolates
Villasis E, Bendezu J, Garro K, Nolazco O, Torres K, Infante B, Gamboa D, Vinetz J. Evaluation of monoclonal antibodies against pfMSP10 for the prospective use on in vitro growth inhibition assays of peruvian P. falciparum isolates. International Journal Of Infectious Diseases 2016, 53: 149. DOI: 10.1016/j.ijid.2016.11.365.Peer-Reviewed Original ResearchEpidemiology of Plasmodium vivax Malaria in Peru
Rosas-Aguirre A, Gamboa D, Manrique P, Conn JE, Moreno M, Lescano AG, Sanchez JF, Rodriguez H, Silva H, Llanos-Cuentas A, Vinetz JM. Epidemiology of Plasmodium vivax Malaria in Peru. American Journal Of Tropical Medicine And Hygiene 2016, 95: 133-144. PMID: 27799639, PMCID: PMC5201219, DOI: 10.4269/ajtmh.16-0268.Peer-Reviewed Original ResearchConceptsMalaria transmissionP. vivaxMalaria controlPlasmodium falciparum malaria casesMicroscopy-confirmed casesP. vivax malaria transmissionFalciparum malaria casesPlasmodium vivax malariaVivax malaria transmissionPublic health problemGlucose-6-phosphate dehydrogenase deficiencyFuture malaria controlImplementation of surveillanceCombination therapyVivax malariaClinical trialsMalaria casesPlasmodium vivaxElimination effortsHealth problemsP. falciparumMosquito transmissionDehydrogenase deficiencyVivaxOngoing surveillance activities
2001
Disruption of Plasmodium falciparumChitinase Markedly Impairs Parasite Invasion of Mosquito Midgut
Tsai Y, Hayward R, Langer R, Fidock D, Vinetz J. Disruption of Plasmodium falciparumChitinase Markedly Impairs Parasite Invasion of Mosquito Midgut. Infection And Immunity 2001, 69: 4048-4054. PMID: 11349075, PMCID: PMC98468, DOI: 10.1128/iai.69.6.4048-4054.2001.Peer-Reviewed Original ResearchConceptsMosquito midgutChitinase geneAvian malaria parasite Plasmodium gallinaceumMalaria parasite Plasmodium gallinaceumMutant ookinetesGenome databasePeritrophic matrixGene productsIntracellular traffickingBp upstreamOokinete invasionStop codonParasite invasionChitinolytic activityPfCHT1MidgutOokinetesOokinete formationGenesConfocal microscopyBlood mealApical endPlasmodium gallinaceumP. falciparumInvasionErythrocytapheresis for Plasmodium falciparum infection complicated by cerebral malaria and hyperparasitemia
Zhang Y, Telleria L, Vinetz J, Yawn D, Rossmann S, Indrikovs A. Erythrocytapheresis for Plasmodium falciparum infection complicated by cerebral malaria and hyperparasitemia. Journal Of Clinical Apheresis 2001, 16: 15-18. PMID: 11309825, DOI: 10.1002/jca.1002.Peer-Reviewed Original ResearchConceptsRed blood cell exchangeCell exchangeAnti-malarial chemotherapyWhole blood exchangeEnd-organ dysfunctionLife-threatening complicationsPlasmodium falciparum infectionRed cell exchangeCirculation of patientsDegree of parasitemiaComplicated malariaCerebral malariaRenal dysfunctionFalciparum infectionHigher parasite loadsBlood exchangePatientsP. falciparumFull recoveryPlasmodium falciparumMalariaParasite loadHyperparasitemiaChemotherapyParasitemia