Continuous Supply of Plasmodium vivax Sporozoites from Colonized Anopheles darlingi in the Peruvian Amazon
Moreno M, Tong-Rios C, Orjuela-Sanchez P, Carrasco-Escobar G, Campo B, Gamboa D, Winzeler EA, Vinetz JM. Continuous Supply of Plasmodium vivax Sporozoites from Colonized Anopheles darlingi in the Peruvian Amazon. ACS Infectious Diseases 2018, 4: 541-548. PMID: 29465219, PMCID: PMC5902790, DOI: 10.1021/acsinfecdis.7b00195.Peer-Reviewed Original ResearchConceptsPlasmodium vivax sporozoitesDonor seraPlasmodium vivax liver stagesStandard membrane feeding assaysMalaria-endemic settingsMembrane feeding assaysSporozoite productionInfectious blood mealInfected subjectsNaïve serumBlood-fed mosquitoesLiver stagesDonor bloodBlood samplesVaccine developmentMosquito midgutSerumBlood mealBloodMosquito survivalSporozoitesMosquitoesAnophelesAnticoagulantsInfection