2016
Increased Nanoparticle Delivery to Brain Tumors by Autocatalytic Priming for Improved Treatment and Imaging
Han L, Kong DK, Zheng MQ, Murikinati S, Ma C, Yuan P, Li L, Tian D, Cai Q, Ye C, Holden D, Park JH, Gao X, Thomas JL, Grutzendler J, Carson RE, Huang Y, Piepmeier JM, Zhou J. Increased Nanoparticle Delivery to Brain Tumors by Autocatalytic Priming for Improved Treatment and Imaging. ACS Nano 2016, 10: 4209-4218. PMID: 26967254, PMCID: PMC5257033, DOI: 10.1021/acsnano.5b07573.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntineoplastic AgentsBiological TransportBlood-Brain BarrierBrain NeoplasmsCell Line, TumorDecanoic AcidsDrug Delivery SystemsEthanolaminesFemaleGenetic TherapyHeterograftsHumansMatrix Metalloproteinase 2MiceMice, Inbred C57BLNanoparticlesOptical ImagingPaclitaxelPermeabilityPolymersPurinesPyrazolesScorpion VenomsTranscytosisTumor MicroenvironmentConceptsBlood-brain barrierLow delivery efficiencyTransport of nanoparticlesCancer gene therapyNanoparticle deliveryMore nanoparticlesBrain tumorsNanoparticlesDelivery efficiencyGene therapySystemic deliveryNPsBrain malignanciesBBB modulatorsPharmacological agentsBrain cancerBrain regionsTumorsDeliveryBrainImproved treatmentInadequate amountsPositive feedback loopChemotherapyMalignancy
1998
Suppression of matrix metalloproteinase-2-mediated cell invasion in U87MG, human glioma cells by anti-microtubule agent: in vitro study
Yoshida D, Piepmeier J, Bergenheim T, Henriksson R, Teramoto A. Suppression of matrix metalloproteinase-2-mediated cell invasion in U87MG, human glioma cells by anti-microtubule agent: in vitro study. British Journal Of Cancer 1998, 77: 21-25. PMID: 9459141, PMCID: PMC2151249, DOI: 10.1038/bjc.1998.4.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic Agents, AlkylatingCollagenEstramustineGelatinasesGlioblastomaHumansMatrix Metalloproteinase 2MetalloendopeptidasesMicrotubulesNeoplasm InvasivenessNeoplasm ProteinsConceptsMatrix metalloproteinase-2Dose-dependent mannerEstramustine groupMetalloproteinase-2Glioma cellsCell invasionMalignant glioma cellsHuman glioma cellsAnti-microtubule agentsControl groupEstramustineMatrix metalloproteinasesInfiltrative capacityCell invasivenessAntimicrotubule agentsCell proliferationSignificant suppressionDisassembly of microtubulesSignificant differencesU87MG cellsLower ratesInvasionHaptoinvasionCellsGroup