2018
Leptomeningeal dissemination from low-grade neuroepithelial CNS tumors in adults: a 15-year experience (P6.159)
Karschnia P, Barbiero F, Schwaiblmair M, Piepmeier J, Huttner A, Becker K, Fulbright R, Baehring J. Leptomeningeal dissemination from low-grade neuroepithelial CNS tumors in adults: a 15-year experience (P6.159). Neurology 2018, 90 DOI: 10.1212/wnl.90.15_supplement.p6.159.Peer-Reviewed Original Research
2016
Increased Nanoparticle Delivery to Brain Tumors by Autocatalytic Priming for Improved Treatment and Imaging
Han L, Kong DK, Zheng MQ, Murikinati S, Ma C, Yuan P, Li L, Tian D, Cai Q, Ye C, Holden D, Park JH, Gao X, Thomas JL, Grutzendler J, Carson RE, Huang Y, Piepmeier JM, Zhou J. Increased Nanoparticle Delivery to Brain Tumors by Autocatalytic Priming for Improved Treatment and Imaging. ACS Nano 2016, 10: 4209-4218. PMID: 26967254, PMCID: PMC5257033, DOI: 10.1021/acsnano.5b07573.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntineoplastic AgentsBiological TransportBlood-Brain BarrierBrain NeoplasmsCell Line, TumorDecanoic AcidsDrug Delivery SystemsEthanolaminesFemaleGenetic TherapyHeterograftsHumansMatrix Metalloproteinase 2MiceMice, Inbred C57BLNanoparticlesOptical ImagingPaclitaxelPermeabilityPolymersPurinesPyrazolesScorpion VenomsTranscytosisTumor MicroenvironmentConceptsBlood-brain barrierLow delivery efficiencyTransport of nanoparticlesCancer gene therapyNanoparticle deliveryMore nanoparticlesBrain tumorsNanoparticlesDelivery efficiencyGene therapySystemic deliveryNPsBrain malignanciesBBB modulatorsPharmacological agentsBrain cancerBrain regionsTumorsDeliveryBrainImproved treatmentInadequate amountsPositive feedback loopChemotherapyMalignancy
2013
Clinical Presentation in Diffuse Low-Grade Gliomas
Torres-Reveron J, Piepmeier J, Becker K. Clinical Presentation in Diffuse Low-Grade Gliomas. 2013, 179-188. DOI: 10.1007/978-1-4471-2213-5_12.Peer-Reviewed Original ResearchDiffuse low-grade gliomasLow-grade gliomasCommon presenting symptomHigh-grade lesionsPrimary brain tumorsStandard imaging modalityPresenting symptomHistopathological findingsClinical presentationTumor sizeNeurological syndromeAnaplastic transformationBrain tumorsMultimodal evaluationConventional imaging technologiesImaging modalitiesActive investigationTumorsGliomasNew advancesSeizuresSyndromeLesionsSymptoms
2012
Low-Grade Gliomas When and How to Treat
Omay SB, Piepmeier JM, Knisely JP. Low-Grade Gliomas When and How to Treat. Hematology/Oncology Clinics Of North America 2012, 26: 797-809. PMID: 22794284, DOI: 10.1016/j.hoc.2012.05.001.Peer-Reviewed Original ResearchConceptsSurgical resectionLow-grade gliomasPatient-specific variablesSame imaging techniqueRadiotherapeutic managementUncommon tumorClinical trialsOperative techniqueHistopathologic characterizationGrade gliomasOptimal managementAdditional studiesGliomasResectionAdequate samplesImaging techniquesPatientsPrognosisManagementTumorsTrialsRole of Neurosurgery and Radiation Therapy in the Management of Brain Tumors
Patel TR, Yu JB, Piepmeier JM. Role of Neurosurgery and Radiation Therapy in the Management of Brain Tumors. Hematology/Oncology Clinics Of North America 2012, 26: 757-777. PMID: 22794282, DOI: 10.1016/j.hoc.2012.04.001.Peer-Reviewed Original Research
2010
Convection-enhanced delivery of camptothecin-loaded polymer nanoparticles for treatment of intracranial tumors
Sawyer AJ, Saucier-Sawyer JK, Booth CJ, Liu J, Patel T, Piepmeier JM, Saltzman WM. Convection-enhanced delivery of camptothecin-loaded polymer nanoparticles for treatment of intracranial tumors. Drug Delivery And Translational Research 2010, 1: 34-42. PMID: 21691426, PMCID: PMC3117592, DOI: 10.1007/s13346-010-0001-3.Peer-Reviewed Original ResearchConvection-enhanced deliveryUnloaded nanoparticlesNanoparticle treatmentPolymer nanoparticlesNanoparticlesRelease nanoparticlesDrug loadingDrug releasePolymer deliveryDirect deliveryIntracranial tumorsSimultaneous controlIntracranial 9L tumorsLong-term survivorsDelivery of chemotherapyDeliveryDiffusional penetrationLocal tissue toxicityMedian survivalChemotherapy agentsTherapeutic benefitGlioblastoma multiformeGliosarcoma cellsTissue toxicityTumors
2009
Anaplastic oligoastrocytoma in Turcot syndrome
Baehring J, Hui P, Piepmeier J, Bannykh SI. Anaplastic oligoastrocytoma in Turcot syndrome. Journal Of Neuro-Oncology 2009, 95: 293-298. PMID: 19495563, DOI: 10.1007/s11060-009-9928-y.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdenosine TriphosphatasesAgedAstrocytomaColorectal Neoplasms, Hereditary NonpolyposisDNA Repair EnzymesDNA, NeoplasmDNA-Binding ProteinsFemaleHumansImmunoenzyme TechniquesMagnetic Resonance ImagingMismatch Repair Endonuclease PMS2MutL Protein Homolog 1MutS Homolog 2 ProteinNuclear ProteinsPedigreePolymerase Chain ReactionConceptsHereditary non-polyposis colorectal cancerTurcot syndromeAnaplastic oligoastrocytomaNon-polyposis colorectal cancerYear old womanHandful of casesColorectal cancerLarge bowelDNA mismatch repair systemOlder womenBrain tumorsTumor DNABody sitesFamilial clusteringGermline mutationsRare variantsSyndromeOligoastrocytomasCancerMismatch repair systemChance occurrenceDetailed molecular dataBowelPathogenesisTumorsPrimary, non-exophytic, optic nerve germ cell tumors
DiLuna ML, Two AM, Levy GH, Patel T, Huttner AJ, Duncan CC, Piepmeier JM. Primary, non-exophytic, optic nerve germ cell tumors. Journal Of Neuro-Oncology 2009, 95: 437-443. PMID: 19554263, DOI: 10.1007/s11060-009-9941-1.Peer-Reviewed Original ResearchConceptsGerm cell tumorsOptic chiasmatic gliomasMalignant mixed germ cell tumorMixed germ cell tumorOptic chiasmCell tumorsOptic chiasm tumorAdrenal axis dysfunctionSub-frontal approachChiasm gliomaChiasmatic gliomasAxis dysfunctionBiopsy confirmationProgressive symptomsVisual lossCase seriesFirst patientTreatment regimensPterional craniotomyDiabetes insipidusTissue diagnosisTissue biopsiesTumorsPatientsChiasmCurrent concepts in the evaluation and management of WHO grade II gliomas
Piepmeier JM. Current concepts in the evaluation and management of WHO grade II gliomas. Journal Of Neuro-Oncology 2009, 92: 253-259. PMID: 19357953, DOI: 10.1007/s11060-009-9870-z.Peer-Reviewed Original ResearchConceptsHigh-grade lesionsGrade II gliomasRandomized clinical trialsLow-grade lesionsAdditional genetic mutationsAdjuvant treatmentAppropriate therapyClinical trialsClinical reportsFatal diseaseLesionsUnique lesionGenetic mutationsCurrent conceptsContinued investigationGliomasRecent findingsSelection criteriaPatientsTherapyTumorsDiseaseTrials
2008
Intracranial benign fibrous histiocytomas: a case report and review
Moliterno JA, Sood S, Zambrano E, Kim JH, Piepmeier JM, Baehring JM. Intracranial benign fibrous histiocytomas: a case report and review. Journal Of Neuro-Oncology 2008, 92: 203-209. PMID: 19030779, DOI: 10.1007/s11060-008-9743-x.Peer-Reviewed Original Research
2006
New methods for direct delivery of chemotherapy for treating brain tumors.
Sawyer AJ, Piepmeier JM, Saltzman WM. New methods for direct delivery of chemotherapy for treating brain tumors. The Yale Journal Of Biology And Medicine 2006, 79: 141-52. PMID: 17940624, PMCID: PMC1994797.Peer-Reviewed Original ResearchConceptsConvection-enhanced deliveryBrain tumorsPrimary malignant brain tumorLocal deliveryBlood-brain barrierMalignant brain tumorsStandard chemotherapeutic drugsBrain cancer treatmentAnti-cancer therapyMedian survivalInfusion siteSevere formMalignant cellsNew delivery strategiesChemotherapy drugsChemotherapyDiagnostic imagingTumorsChemotherapeutic drugsCancer treatmentDrugsInvasive cellsSource of drugsDelivery strategiesBrain
2005
Transcallosal Transchoroidal Approach to Tumors of the Third Ventricle
Kasowski HJ, Nahed BV, Piepmeier JM. Transcallosal Transchoroidal Approach to Tumors of the Third Ventricle. Neurosurgery 2005, 57: ons-361-ons-366. PMID: 16234686, DOI: 10.1227/01.neu.0000176652.59747.40.Peer-Reviewed Original Research
2004
Surgical Resection for Patients with Benign Primary Brain Tumors and Low Grade Gliomas
Piepmeier J, Baehring JM. Surgical Resection for Patients with Benign Primary Brain Tumors and Low Grade Gliomas. Journal Of Neuro-Oncology 2004, 69: 55-65. PMID: 15527080, DOI: 10.1023/b:neon.0000041871.46785.53.Peer-Reviewed Original ResearchConceptsPrimary brain tumorsBrain tumorsNeuroepithelial tumorsBenign primary brain tumorsMajority of patientsAdverse treatment effectsBenefits of therapyLow-grade tumorsLow-grade gliomasSurgical resectionInitial diagnosisMalignant degenerationPrimary neoplasmsSurgical managementSeizure focusBrain parenchymaChordoid gliomaNeurosurgical interventionThird ventricleChoroid plexusGrade gliomasTumorsUnknown originHeterogeneous groupCell pool
1997
Tumors of the Lateral Ventricle
Sun P, Piepmeier J. Tumors of the Lateral Ventricle. Neurosurgery Quarterly 1997, 7: 286-300. DOI: 10.1097/00013414-199712000-00005.Peer-Reviewed Original ResearchLateral ventricleCornerstone of therapyChoroid plexus tumorsBenign biological behaviorVariety of tumorsNeurologic deficitsPatient agePlexus tumorsSurgical approachNeuropsychological sequelaeLarge lesionsVentricular locationTumorsBiological behaviorVentricleAgeComplicationsSequelaeHydrocephalusNeurocytomaTherapyLesionsMeningiomasSymptomsSubependymomaLow-grade gliomas of chronic epilepsy: A distinct clinical and pathological entity
Bartolomei J, Christopher S, Vives K, Spencer D, Piepmeier J. Low-grade gliomas of chronic epilepsy: A distinct clinical and pathological entity. Journal Of Neuro-Oncology 1997, 34: 79-84. PMID: 9210054, DOI: 10.1023/a:1005711321343.Peer-Reviewed Original ResearchConceptsLow-grade gliomasChronic epilepsyDysembryoplastic neuroepithelial tumorPathological entityLong-term patient outcomesSpecific pathological entityManagement of patientsResults of patientsDistinct pathological entityLack of mortalityPreoperative seizuresNeuroepithelial tumorsTumor recurrencePatient outcomesAnaplastic transformationEpilepsySame tumorGliomasCortical locationTumorsPatientsRecurrenceSeizuresPopulationMortality
1996
Tumors and approaches to the lateral ventricles
Piepmeier J. Tumors and approaches to the lateral ventricles. Journal Of Neuro-Oncology 1996, 30: 267-274. PMID: 8943102, DOI: 10.1007/bf00177278.Peer-Reviewed Original ResearchConceptsLateral ventricular tumorsVentricular tumorsLateral ventricleSuccessful surgical therapyUnique surgical challengeVariety of tumorsSurgical therapyNonspecific symptomsSurgical challengeFurther injuryMedical attentionNeurological problemsCognitive impairmentCognitive functionTumorsOptimal outcomesLesionsVentricleHydrocephalusPatientsTherapyInjurySymptomsBEHAB (brain enriched hyaluronan binding) is expressed in surgical samples of glioma and in intracranial grafts of invasive glioma cell lines.
Jaworski D, Kelly G, Piepmeier J, Hockfield S. BEHAB (brain enriched hyaluronan binding) is expressed in surgical samples of glioma and in intracranial grafts of invasive glioma cell lines. Cancer Research 1996, 56: 2293-8. PMID: 8625302.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnimalsBiomarkers, TumorBrain NeoplasmsBrevicanCarrier ProteinsChild, PreschoolChondroitin Sulfate ProteoglycansFemaleGliomaHumansHyaluronic AcidIn Situ HybridizationLectins, C-TypeMaleMiddle AgedNeoplasm InvasivenessNeoplasm ProteinsNeoplasm TransplantationNerve Tissue ProteinsRatsRats, Inbred LewRats, Sprague-DawleyTumor Cells, CulturedConceptsGlioma cell linesSurgical samplesIntracranial graftsCell linesAdult human cortexInvasive glioma cell linesBrain metastasesNonglial tumorsNoninvasive cell linesMalignant gliomasExtracellular brainNormal brainTumor invasionHyaluronan-binding proteinHuman cortexGliomasTumorsInvasive behaviorStandard cell culture conditionsGraftBrainBEHABCell culture conditionsSelective markerMetastasisIn vitro and in vivo inhibition of glioblastoma and neuroblastoma with MDL101731, a novel ribonucleoside diphosphate reductase inhibitor.
Piepmeier J, Rabidou N, Schold S, Bitonti A, Prakash N, Bush T. In vitro and in vivo inhibition of glioblastoma and neuroblastoma with MDL101731, a novel ribonucleoside diphosphate reductase inhibitor. Cancer Research 1996, 56: 359-61. PMID: 8542592.Peer-Reviewed Original ResearchConceptsMalignant brain tumorsMedian survivalControl animalsAthymic miceBrain tumorsReductase inhibitorsHuman malignant brain tumorsHuman glioblastomaDays of treatmentSK-N-MCConcentration-dependent inhibitionTumor regressionIntracerebral implantsIntracerebral xenograftsXenograft modelGlioblastoma cell linesVivo inhibitionPotent antiproliferative activityNeuroblastomaGlioblastomaSurvivalCell linesXenograftsNanomolar concentrationsTumors
1993
Low-grade astrocytomas may arise from different astrocyte lineages.
Piepmeier J, Fried I, Makuch R. Low-grade astrocytomas may arise from different astrocyte lineages. Neurosurgery 1993, 33: 627-32. PMID: 8232801, DOI: 10.1227/00006123-199310000-00010.Peer-Reviewed Original ResearchConceptsLow-grade astrocytomasGlial fibrillary acidic protein-positive cellsFibrillary acidic proteinProtein-positive cellsAstrocyte lineagePreoperative symptomsAnti-glial fibrillary acidic proteinAcidic proteinGlial fibrillary acidic proteinLong preoperative historyCommon histological featuresDifferent clinical manifestationsPercentage of cellsPreoperative historyClinical manifestationsHistological featuresImaging featuresRate of proliferationImmunohistochemical analysisAstrocytic phenotypeNeoplastic cellsType 2White matterAstrocytomasTumors
1991
Surgical Management of Lateral Ventricular Tumors
Piepmeier J, Sass K. Surgical Management of Lateral Ventricular Tumors. Developments In Oncology 1991, 333-335. DOI: 10.1007/978-94-011-3152-0_59.Peer-Reviewed Original ResearchLateral ventricular tumorsVentricular tumorsRisk of seizuresTranscallosal surgeryConsecutive patientsNeurologic examinationNeurologic functionSurgical treatmentSurgical managementRange of pathologiesTranscallosal approachTumor exposureCorpus callosumExcessive retractionOperative procedureTumorsCognitive functionSevere memory problemsPatientsSurgeryRelative deficitMemory problemsRelative liabilityDeficitsPerformance IQ