Recapitulation of Prognostic Mutational Subtyping Utilizing F1H in GOYA and CAVALLI and the Potential to Highlight Benefit of Targeted Therapy in De Novo DLBCL
Kim E, Fan J, Bolen C, Bazeos A, Jiang Y, Balasubramanian S, Balakrishnan R, Knapp A, Humphrey K, Nielsen T, Venstrom J, Hernandez G, Paulson J. Recapitulation of Prognostic Mutational Subtyping Utilizing F1H in GOYA and CAVALLI and the Potential to Highlight Benefit of Targeted Therapy in De Novo DLBCL. Blood 2019, 134: 2788. DOI: 10.1182/blood-2019-124687.Peer-Reviewed Original ResearchWhole-exome sequencingDiffuse large B-cell lymphomaExome-sequencing dataInternational Prognostic IndexBCL2 inhibitor venetoclaxHigh-risk groupRNA gene expression dataGene expression dataTargeted therapyClinical outcomesCopy number amplificationNext-generation sequencingDe novo diffuse large B-cell lymphomaAssociated with inferior clinical outcomesLarge B-cell lymphomaGenetic risk modelsNucleotide variantsAdverse prognostic impactClinical prognostic scoresB-cell lymphomaInferior clinical outcomesImprove survival outcomesExpression dataExome sequencingClinically heterogeneous disease