2021
Multivariable association discovery in population-scale meta-omics studies
Mallick H, Rahnavard A, McIver L, Ma S, Zhang Y, Nguyen L, Tickle T, Weingart G, Ren B, Schwager E, Chatterjee S, Thompson K, Wilkinson J, Subramanian A, Lu Y, Waldron L, Paulson J, Franzosa E, Bravo H, Huttenhower C. Multivariable association discovery in population-scale meta-omics studies. PLOS Computational Biology 2021, 17: e1009442. PMID: 34784344, PMCID: PMC8714082, DOI: 10.1371/journal.pcbi.1009442.Peer-Reviewed Original ResearchConceptsMicrobial community measurementsMeta-omics studiesMicrobial community featuresMulti-omics datasetsControlling false discoveriesLandscape of inflammatory bowel diseaseHuman microbiomeMaAsLinMulti-omicsOmics profilesFalse discoveriesCommunity measuresMicrobiomeEnvironmental conditionsInflammatory bowel diseaseCommunity featuresHealth outcomesAssociation discoveryMultivariate associationsMultiple covariatesEpidemiological studiesLongitudinal designObservational studyStatistical powerZero-inflation
2020
MicrobiomeExplorer: an R package for the analysis and visualization of microbial communities
Reeder J, Huang M, Kaminker J, Paulson J. MicrobiomeExplorer: an R package for the analysis and visualization of microbial communities. Bioinformatics 2020, 37: 1317-1318. PMID: 32960962, PMCID: PMC8193707, DOI: 10.1093/bioinformatics/btaa838.Peer-Reviewed Original ResearchmicrobiomeDASim: Simulating longitudinal differential abundance for microbiome data
Williams J, Bravo H, Tom J, Paulson J. microbiomeDASim: Simulating longitudinal differential abundance for microbiome data. F1000Research 2020, 8: 1769. PMID: 32148761, PMCID: PMC7047923, DOI: 10.12688/f1000research.20660.2.Peer-Reviewed Original Research
2019
microbiomeDASim: Simulating longitudinal differential abundance for microbiome data
Williams J, Bravo H, Tom J, Paulson J. microbiomeDASim: Simulating longitudinal differential abundance for microbiome data. F1000Research 2019, 8: 1769. DOI: 10.12688/f1000research.20660.1.Peer-Reviewed Original Research
2018
Metaviz: interactive statistical and visual analysis of metagenomic data
Wagner J, Chelaru F, Kancherla J, Paulson J, Zhang A, Felix V, Mahurkar A, Elmqvist N, Bravo H. Metaviz: interactive statistical and visual analysis of metagenomic data. Nucleic Acids Research 2018, 46: gky136-. PMID: 29529268, PMCID: PMC5887897, DOI: 10.1093/nar/gky136.Peer-Reviewed Original ResearchConceptsWeb servicesInteractive exploratory data analysisMetagenomic shotgun sequencingState-of-the-artState-of-the-art analysis toolsMetagenomic samplesShotgun sequencingUser navigationMicrobial communitiesCommunity profilesData featuresData valuesDisease phenotypeMarker genesMetavizUsersData resourcesProcess dataVisual analysisAnalysis toolsHierarchical structureSignificant effortBioconductorMetagenomicsMicrobiome
2017
Simplified and representative bacterial community of maize roots
Niu B, Paulson J, Zheng X, Kolter R. Simplified and representative bacterial community of maize roots. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: e2450-e2459. PMID: 28275097, PMCID: PMC5373366, DOI: 10.1073/pnas.1616148114.Peer-Reviewed Original ResearchConceptsCommunity assemblyBacterial communitiesDynamics of community assemblyComposition of plant microbiomesBacterial interspecies interactionsSynthetic bacterial communityPlant-associated microbesCulture-dependent methodsRoot microbiome assemblyHost-mediated selectionFusarium verticillioides</i>Maize rootsRoot microbiotaMicrobiome assemblyPlant microbiomeRoot microbiomePlant hostsHost genotypeKeystone speciesDominant phylaAbiotic factorsInterspecies interactionsModel ecosystemsMicrobiomeMaize seedlings
2016
Privacy-preserving microbiome analysis using secure computation
Wagner J, Paulson J, Wang X, Bhattacharjee B, Corrada Bravo H. Privacy-preserving microbiome analysis using secure computation. Bioinformatics 2016, 32: 1873-1879. PMID: 26873931, PMCID: PMC4908319, DOI: 10.1093/bioinformatics/btw073.Peer-Reviewed Original ResearchConceptsDNA of micro-organismsMicrobiome research communityPrivacy concernsSensitive attributesResearch participant dataFeature countsSharing dataSupplementary dataMetagenomic analysisResearch datasetsMicrobiome sequencingSequencing studiesMicrobial DNAHuman DNAResearch communityMicrobiome analysisMicrobiomeDNAAnalysis toolsDatasetComputerMicro-organismsBioinformaticsImplementationIndividual collections