2023
Transcriptional immunogenomic analysis reveals distinct immunological clusters in paediatric nervous system tumours
Nabbi A, Beck P, Delaidelli A, Oldridge D, Sudhaman S, Zhu K, Yang S, Mulder D, Bruce J, Paulson J, Raman P, Zhu Y, Resnick A, Sorensen P, Sill M, Brabetz S, Lambo S, Malkin D, Johann P, Kool M, Jones D, Pfister S, Jäger N, Pugh T. Transcriptional immunogenomic analysis reveals distinct immunological clusters in paediatric nervous system tumours. Genome Medicine 2023, 15: 67. PMID: 37679810, PMCID: PMC10486055, DOI: 10.1186/s13073-023-01219-x.Peer-Reviewed Original ResearchConceptsChimeric antigen receptorNervous system tumorsImmune clustersImmunogenomic analysisSystem tumorsCancer typesImmune checkpoint inhibitorsT-cell therapyPaediatric solid tumoursTumor mutational burdenImmune cell frequenciesPotential immune biomarkersImmune infiltration levelsB cell repertoireDeterminants of immune responseVariable response ratesBackgroundCancer immunotherapyImmunogenomic profilingMyeloid predominanceCheckpoint inhibitorsImmunotherapeutic strategiesImmunotherapy approachesImmune compositionImmune neutralizationImmune desert
2019
Abstract 2891: Landscape of infiltrating immune repertoire in pediatric solid tumors
Nabbi A, Jäger N, Sudhaman S, Sun P, Yang S, Zhu K, Kool M, Rathi K, Kalletla K, Raman P, Zhu Y, Paulson J, Jones D, Tabori U, Resnick A, Pfister S, Pugh T. Abstract 2891: Landscape of infiltrating immune repertoire in pediatric solid tumors. Cancer Research 2019, 79: 2891-2891. DOI: 10.1158/1538-7445.am2019-2891.Peer-Reviewed Original ResearchPediatric solid tumorsTumor microenvironmentSolid tumorsConstitutional mismatch repair deficiencyImmune repertoirePediatric cancerExpression profiles of immune cellsCompared to adult counterpartsAssociated with clinical responseImmune checkpoint gene expressionProfile of immune cellsImmune checkpoint blockadeAntigen presentation machineryCheckpoint gene expressionDeterminants of immune responseT cell receptorChildren's Brain Tumor Tissue ConsortiumInternational Cancer Genome ConsortiumCheckpoint blockadeImmunosuppressive environmentPresentation machineryRare malignancyCancer Genome ConsortiumClinical responseMismatch repair deficiency