Characterization of RAGE, HMGB1, and S100β in Inflammation-Induced Preterm Birth and Fetal Tissue Injury
Buhimschi CS, Baumbusch MA, Dulay AT, Oliver EA, Lee S, Zhao G, Bhandari V, Ehrenkranz RA, Weiner CP, Madri JA, Buhimschi IA. Characterization of RAGE, HMGB1, and S100β in Inflammation-Induced Preterm Birth and Fetal Tissue Injury. American Journal Of Pathology 2009, 175: 958-975. PMID: 19679874, PMCID: PMC2731116, DOI: 10.2353/ajpath.2009.090156.Peer-Reviewed Original ResearchConceptsDamage-associated molecular pattern moleculesMolecular pattern moleculesPreterm birthTissue injuryPattern moleculesInflammation-induced preterm birthBiology of RAGEExpression of RAGERole of RAGERobust inflammatory responseRelease of HMGB1Fetal inflammationFetal injuryFetal circulationFetal damageImmune activationInterleukin-6Inflammatory responseAdvanced glycationAnimal modelsCellular injuryHuman fetusesTissue damageS100 proteinInjury