2003
Transcriptional Up-regulation of Endothelial Cell Matrix Metalloproteinase-2 in Response to Extracellular Cues Involves GATA-2*
Han X, Boyd PJ, Colgan S, Madri JA, Haas TL. Transcriptional Up-regulation of Endothelial Cell Matrix Metalloproteinase-2 in Response to Extracellular Cues Involves GATA-2*. Journal Of Biological Chemistry 2003, 278: 47785-47791. PMID: 14512418, DOI: 10.1074/jbc.m309482200.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceBlotting, NorthernBlotting, WesternCell NucleusCells, CulturedCollagenCOS CellsDNA-Binding ProteinsEndothelial CellsExtracellular MatrixGATA2 Transcription FactorGelatinGenes, ReporterLuciferasesMatrix Metalloproteinase 2MicrocirculationMolecular Sequence DataNeovascularization, PhysiologicPhenotypePromoter Regions, GeneticProtein BindingRatsTranscription FactorsTranscription, GeneticTranscriptional ActivationTransfectionUp-Regulation
1999
Egr-1 Mediates Extracellular Matrix-driven Transcription of Membrane Type 1 Matrix Metalloproteinase in Endothelium*
Haas T, Stitelman D, Davis S, Apte S, Madri J. Egr-1 Mediates Extracellular Matrix-driven Transcription of Membrane Type 1 Matrix Metalloproteinase in Endothelium*. Journal Of Biological Chemistry 1999, 274: 22679-22685. PMID: 10428849, DOI: 10.1074/jbc.274.32.22679.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceCloning, MolecularDNA-Binding ProteinsEarly Growth Response Protein 1Endothelium, VascularExtracellular MatrixGene Expression Regulation, EnzymologicHalf-LifeImmediate-Early ProteinsMatrix Metalloproteinase 14Matrix Metalloproteinases, Membrane-AssociatedMetalloendopeptidasesMiceMolecular Sequence DataNeovascularization, PhysiologicProtein BindingRatsRNA, MessengerSp1 Transcription FactorTranscription FactorsTranscription, GeneticUp-RegulationConceptsMembrane type 1 matrix metalloproteinaseEgr-1MT1-MMPTranscription factor Egr-1Number of proteinsExtracellular matrix environmentEnhanced transcriptional activityEndothelial cellsTranscriptional activityPromoter correlatesIncreased transcriptionCellular invasionInvasive phenotypeMatrix metalloproteinaseTranscriptionMatrix environmentMatrix metalloproteinase activityMetalloproteinase activityCellsMatrix metalloproteinasesInvasionIncrease productionAngiogenesisMetalloproteinaseProtein
1996
Laminin promotes differentiation of NB4 promyelocytic leukemia cells with all-trans retinoic acid.
Becker P, Li Z, Potselueva T, Madri J, Newburger P, Berliner N. Laminin promotes differentiation of NB4 promyelocytic leukemia cells with all-trans retinoic acid. Blood 1996, 88: 261-7. PMID: 8704182, DOI: 10.1182/blood.v88.1.261.bloodjournal881261.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, CDBase SequenceCalciumCell Culture TechniquesCell DifferentiationCell DivisionCollagenDrug SynergismFibronectinsGene Expression Regulation, LeukemicHumansIntegrin alpha6Integrin beta1IonomycinIonophoresLamininLeukemia, Promyelocytic, AcuteMolecular Sequence DataNeoplasm ProteinsNeoplastic Stem CellsOxidation-ReductionPolymerase Chain ReactionReceptors, LamininTretinoinTumor Cells, CulturedConceptsAlpha 6 integrinTrans retinoic acidNB4 promyelocytic leukemia cellsPromyelocytic leukemia cellsMorphologic maturationLeukemia cellsRetinoic acidReverse transcription-polymerase chain reactionTranscription-polymerase chain reactionSecondary granule proteinsPresence of ionomycinPromyelocytic leukemia cell lineHistologic appearanceHours of exposureLeukemia cell linesMinimal maturationFlow cytometryHigh-level surface expressionDifferentiation agentsCollagen type INB4 cellsLaminin receptorATRAExtracellular matrix componentsCell proliferation
1993
Characterization of distinct functional domains of transforming growth factor beta.
Burmester J, Qian S, Roberts A, Huang A, Amatayakul-Chantler S, Suardet L, Odartchenko N, Madri J, Sporn M. Characterization of distinct functional domains of transforming growth factor beta. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 8628-8632. PMID: 7690965, PMCID: PMC47411, DOI: 10.1073/pnas.90.18.8628.Peer-Reviewed Original ResearchMeSH Keywords3T3 CellsAlpha-MacroglobulinsAmino Acid SequenceAnimalsCattleCHO CellsCricetinaeDose-Response Relationship, DrugEndothelium, VascularHeartHumansKineticsMiceMolecular Sequence DataReceptors, Cell SurfaceReceptors, Transforming Growth Factor betaRecombinant Fusion ProteinsRecombinant ProteinsTransforming Growth Factor betaUmbilical VeinsConceptsGrowth factor betaFactor betaHuman colorectal cancer cell linesColorectal cancer cell linesLS513 cellsCancer cell linesTGF-beta moleculesCell linesAlphaBiological potencyBetaCellsCertain cellsAmino acidsPotencyDistinct functional domainsAdditional amino acidsDifferent isoformsIsoformsDistinct isoformsFunctional domainsChimeric proteinBiologically active Arg-Gly-Asp oligopeptides assume a type II beta-turn in solution.
Johnson W, Pagano T, Basson C, Madri J, Gooley P, Armitage I. Biologically active Arg-Gly-Asp oligopeptides assume a type II beta-turn in solution. Biochemistry 1993, 32: 268-73. PMID: 8418846, DOI: 10.1021/bi00052a034.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceHydrogen-Ion ConcentrationIntegrinsMagnetic Resonance SpectroscopyMolecular Sequence DataOligopeptidesProtein Structure, SecondarySolutions
1992
Endothelial cells interact with the core protein of basement membrane perlecan through beta 1 and beta 3 integrins: an adhesion modulated by glycosaminoglycan.
Hayashi K, Madri J, Yurchenco P. Endothelial cells interact with the core protein of basement membrane perlecan through beta 1 and beta 3 integrins: an adhesion modulated by glycosaminoglycan. Journal Of Cell Biology 1992, 119: 945-959. PMID: 1385448, PMCID: PMC2289694, DOI: 10.1083/jcb.119.4.945.Peer-Reviewed Original ResearchAcidic fibroblast growth factor-Pseudomonas exotoxin chimeric protein elicits antiangiogenic effects on endothelial cells.
Merwin J, Lynch M, Madri J, Pastan I, Siegall C. Acidic fibroblast growth factor-Pseudomonas exotoxin chimeric protein elicits antiangiogenic effects on endothelial cells. Cancer Research 1992, 52: 4995-5001. PMID: 1381275.Peer-Reviewed Original ResearchMeSH KeywordsADP Ribose TransferasesAmino Acid SequenceAnimalsBacterial ToxinsCell MovementCell SurvivalCells, CulturedEndothelium, VascularExotoxinsFibroblast Growth Factor 1In Vitro TechniquesMolecular Sequence DataNeovascularization, PathologicRatsRats, Inbred StrainsReceptors, Cell SurfaceReceptors, Fibroblast Growth FactorRecombinant Fusion ProteinsVirulence FactorsConceptsGrowth factor beta 1Endothelial cellsChimeric toxinBeta 1Inhibitory effectDose-dependent toxic effectAnti-angiogenic agentsMicrovascular endothelial cellsAcidic fibroblast growth factorFibroblast growth factorSignificant inhibitory effectMicrovascular endotheliumAntiangiogenic effectsPseudomonas exotoxinTumor cell linesAntimigratory effectsGrowth factorAngiogenic responseProtein synthesisCell linesFGF receptorsToxic effectsCell deathEndotheliumCell viability analysisIdentification of a structural domain that distinguishes the actions of the type 1 and 2 isoforms of transforming growth factor beta on endothelial cells.
Qian S, Burmester J, Merwin J, Madri J, Sporn M, Roberts A. Identification of a structural domain that distinguishes the actions of the type 1 and 2 isoforms of transforming growth factor beta on endothelial cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 1992, 89: 6290-6294. PMID: 1631120, PMCID: PMC49486, DOI: 10.1073/pnas.89.14.6290.Peer-Reviewed Original ResearchConceptsEndothelial cellsFetal bovine heart endothelial cellsMicrovascular endothelial cellsGrowth factor betaHeart endothelial cellsAortic endothelial cellsBovine aortic endothelial cellsFactor betaType 1Amino acids 40Beta moleculesInhibition of growthAmino acids 1Biological potencyCellsGreater activityMajor histocompatibility complex (MHC) control of CD4 T cell subset activation. II. A single peptide induces either humoral or cell‐mediated responses in mice of distinct MHC genotype
Murray J, Pfeiffer C, Madri J, Bottomly K. Major histocompatibility complex (MHC) control of CD4 T cell subset activation. II. A single peptide induces either humoral or cell‐mediated responses in mice of distinct MHC genotype. European Journal Of Immunology 1992, 22: 559-565. PMID: 1347015, DOI: 10.1002/eji.1830220239.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntibody FormationAntigen-Presenting CellsCD4-Positive T-LymphocytesCollagenGenes, MHC Class IIHaptensHumansImmunity, CellularImmunologic MemoryLymph NodesLymphocyte ActivationLymphocyte CooperationMajor Histocompatibility ComplexMiceMolecular Sequence DataPeptidesT-Lymphocytes, Helper-Inducer
1990
Spatiotemporal segregation of endothelial cell integrin and nonintegrin extracellular matrix-binding proteins during adhesion events.
Basson C, Knowles W, Bell L, Albelda S, Castronovo V, Liotta L, Madri J. Spatiotemporal segregation of endothelial cell integrin and nonintegrin extracellular matrix-binding proteins during adhesion events. Journal Of Cell Biology 1990, 110: 789-801. PMID: 2407741, PMCID: PMC2116027, DOI: 10.1083/jcb.110.3.789.Peer-Reviewed Original ResearchConceptsMatrix-binding proteinsBeta 1 integrinLow-affinity integrinsRGD-dependent receptorExtracellular matrix-binding proteinsIntegrin beta 1Integrin subclassesBeta 1Beta 3Endothelial cell integrinsPeptide inhibitionBAECFibrinogenBAEC migrationCell integrinsLamininPerinuclear vesiclesIntegrinsAlpha subunitMatrix proteinsAdhesive eventsFibronectinPeptides