2006
PECAM‐1 modulates thrombin‐induced tissue factor expression on endothelial cells
Zhang JJ, Kelm RJ, Biswas P, Kashgarian M, Madri JA. PECAM‐1 modulates thrombin‐induced tissue factor expression on endothelial cells. Journal Of Cellular Physiology 2006, 210: 527-537. PMID: 17111362, DOI: 10.1002/jcp.20908.Peer-Reviewed Original ResearchMeSH KeywordsActive Transport, Cell NucleusAnimalsApoptosisBlood CoagulationCells, CulturedDisease Models, AnimalDown-RegulationEarly Growth Response Protein 1Endothelial CellsFibrinHumansKidneyMaleMAP Kinase Signaling SystemMiceMice, Inbred C57BLMice, KnockoutOligodeoxyribonucleotides, AntisensePlatelet Endothelial Cell Adhesion Molecule-1Receptor, PAR-1Reperfusion InjuryRNA, MessengerThrombinThromboplastinThrombosisConceptsTissue factor expressionHuman umbilical vein endothelial cellsFactor expressionPECAM-1TF inductionEndothelial cellsP38 phosphorylationCell adhesion molecule-1Transient renal ischemiaThrombin receptor PAR-1PAR-1 antagonistsPertussis toxin inhibitionAdhesion molecule-1Endothelial cell adhesion molecule-1Receptor PAR-1PI3K-Akt phosphorylationGalphai/o subunitsPECAM-1 expressionRho-kinase activityUmbilical vein endothelial cellsVein endothelial cellsRenal ischemiaEgr-1 expressionFibrin depositionPlatelet function
1996
Amelioration of lupus-like autoimmune disease in NZB/WF1 mice after treatment with a blocking monoclonal antibody specific for complement component C5.
Wang Y, Hu Q, Madri J, Rollins S, Chodera A, Matis L. Amelioration of lupus-like autoimmune disease in NZB/WF1 mice after treatment with a blocking monoclonal antibody specific for complement component C5. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 8563-8568. PMID: 8710910, PMCID: PMC38712, DOI: 10.1073/pnas.93.16.8563.Peer-Reviewed Original ResearchConceptsNZB/W F1 miceNZB/WF1 miceLupus-like autoimmune diseaseW F1 miceF1 miceAutoimmune diseasesNew Zealand Black x New Zealand White F1 miceFemale NZB/W F1 miceFemale NZB/WF1 miceHuman systemic lupus erythematosusMonoclonal antibodiesCourse of glomerulonephritisSystemic lupus erythematosusImmune complex glomerulonephritisSystemic complement activationWhite F1 miceImmune complex nephritisMonths of ageSevere glomerulonephritisAntinuclear antibodiesComplement component C5Continuous therapyAutoimmune syndromeLupus erythematosusRenal disease
1980
Ultrastructural localization of fibronectin and laminin in the basement membranes of the murine kidney.
Madri J, Roll F, Furthmayr H, Foidart J. Ultrastructural localization of fibronectin and laminin in the basement membranes of the murine kidney. Journal Of Cell Biology 1980, 86: 682-687. PMID: 6995470, PMCID: PMC2111490, DOI: 10.1083/jcb.86.2.682.Peer-Reviewed Original ResearchConceptsTubular basement membraneMesangial areaBowman's capsuleMesangial matrixBasement membraneFrozen sectionsNormal murine kidneyMurine kidneyAffinity-purified rabbit antibodiesConventional frozen sectionsGlomerular basement membraneSheep anti-rabbit IgGLaminin labellingThick frozen sectionsImmunofluorescence stainingSpecific antibodiesRabbit antibodiesLamina rara internaMesangial cell processesKidneyUltrastructural levelCapsuleAntibodiesAnti-rabbit IgGLamininCodistribution of collagen types IV and AB2 in basement membranes and mesangium of the kidney. an immunoferritin study of ultrathin frozen sections.
Roll FJ, Madri JA, Albert J, Furthmayr H. Codistribution of collagen types IV and AB2 in basement membranes and mesangium of the kidney. an immunoferritin study of ultrathin frozen sections. Journal Of Cell Biology 1980, 85: 597-616. PMID: 6993495, PMCID: PMC2111464, DOI: 10.1083/jcb.85.3.597.Peer-Reviewed Original Research