Effects of a novel tylophorine analog on collagen‐induced arthritis through inhibition of the innate immune response
You X, Pan M, Gao W, Shiah H, Tao J, Zhang D, Koumpouras F, Wang S, Zhao H, Madri JA, Baker D, Cheng Y, Yin Z. Effects of a novel tylophorine analog on collagen‐induced arthritis through inhibition of the innate immune response. Arthritis & Rheumatism 2006, 54: 877-886. PMID: 16508970, DOI: 10.1002/art.21640.Peer-Reviewed Original ResearchConceptsCollagen-induced arthritisBone marrow-derived dendritic cellsMarrow-derived dendritic cellsInnate immune responseDendritic cellsProinflammatory cytokinesTylophorine analogsImmune responseOnset of CIAProgression of CIACytometric bead array analysisTumor necrosis factor alphaB cell antibody responseDevelopment of arthritisNecrosis factor alphaT cell proliferationBead array analysisNovel therapeutic agentsEnzyme-linked immunosorbent assayInflammatory arthritisJoint inflammationInflammatory cytokinesAntibody responseClinical severityPathologic changes