2013
Modeling the Neurovascular Niche: Unbiased Transcriptome Analysis of the Murine Subventricular Zone in Response to Hypoxic Insult
Li Q, Canosa S, Flynn K, Michaud M, Krauthammer M, Madri JA. Modeling the Neurovascular Niche: Unbiased Transcriptome Analysis of the Murine Subventricular Zone in Response to Hypoxic Insult. PLOS ONE 2013, 8: e76265. PMID: 24146847, PMCID: PMC3795763, DOI: 10.1371/journal.pone.0076265.Peer-Reviewed Original ResearchConceptsSubventricular zoneRepair/recoveryChronic hypoxiaPremature infant populationMurine subventricular zoneEarly intervention approachesNeurodevelopmental handicapPremature infantsNeurovascular nicheHypoxic insultCD1 miceInfant populationMotor responsivenessCNS tissueDisease severityMRNA expressionUnbiased transcriptome analysisDifferent behavioral parametersNeural functionMouse strainsDifferential responseHypoxiaHypoxic conditionsRange of responsivenessIntervention approaches
1992
Indomethacin promotes germinal matrix microvessel maturation in the newborn beagle pup.
Ment L, Stewart W, Ardito T, Huang E, Madri J. Indomethacin promotes germinal matrix microvessel maturation in the newborn beagle pup. Stroke 1992, 23: 1132-1137. PMID: 1636188, DOI: 10.1161/01.str.23.8.1132.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBrainCerebral HemorrhageCerebral VentriclesCollagenDogsGerm LayersIndomethacinIntracellular FluidLamininMicrocirculationConceptsNewborn beagle pupsPostnatal day 2Germinal matrixPostnatal ageBeagle pupsIntraventricular hemorrhageVessel densityDay 2Postnatal day 1Laminin depositionMechanism of actionMicrovessel maturationStudy medicationBeta 1 integrinImmunohistochemical studyPostnatal dayDose i.Animal studiesDay 1IndomethacinNewborn pupsHemorrhageBasement membrane depositionBuffered formalinCollagen staining
1991
Beagle pup germinal matrix maturation studies.
Ment L, Stewart W, Ardito T, Madri J. Beagle pup germinal matrix maturation studies. Stroke 1991, 22: 390-395. PMID: 2003309, DOI: 10.1161/01.str.22.3.390.Peer-Reviewed Original ResearchConceptsAlpha-smooth muscle actinIntraventricular hemorrhageDay 1Muscle actinRisk periodGlial fibrillary acidic proteinGerminal matrix vasculatureNewborn beagle pupsPostnatal day 1Postnatal day 4Postnatal day 10Fibrillary acidic proteinGerminal matrix vesselsGerminal matrix tissuePreterm infantsImmunohistochemical studyPerinatal maturationPostnatal dayBeagle pupsVessel densityHemorrhageExtracellular matrix componentsDay 4Day 10Basement membrane proteins