2009
Modeling the neurovascular niche: implications for recovery from CNS injury.
Madri JA. Modeling the neurovascular niche: implications for recovery from CNS injury. Journal Of Physiology And Pharmacology 2009, 60 Suppl 4: 95-104. PMID: 20083857.Peer-Reviewed Original ResearchConceptsNeurovascular nicheCNS injuryHIF-1alphaSpinal cord injuryNeural stem cell survivalNeurogenic zonesCord injuryTraumatic brainMurine modelSDF-1Sublethal hypoxiaInjuryStem cell survivalNRP-1Neurodegenerative diseasesEndothelial cellsHypoxiaExpression levelsSurvivalCell survivalFocused reviewDiseaseVariable responseTrkBBDNF
2008
Engineering angiogenesis following spinal cord injury: a coculture of neural progenitor and endothelial cells in a degradable polymer implant leads to an increase in vessel density and formation of the blood–spinal cord barrier
Rauch MF, Hynes SR, Bertram J, Redmond A, Robinson R, Williams C, Xu H, Madri JA, Lavik EB. Engineering angiogenesis following spinal cord injury: a coculture of neural progenitor and endothelial cells in a degradable polymer implant leads to an increase in vessel density and formation of the blood–spinal cord barrier. European Journal Of Neuroscience 2008, 29: 132-145. PMID: 19120441, PMCID: PMC2764251, DOI: 10.1111/j.1460-9568.2008.06567.x.Peer-Reviewed Original ResearchMeSH KeywordsAbsorbable ImplantsAnimalsBlood VesselsBlood-Brain BarrierCells, CulturedCoculture TechniquesDisease Models, AnimalEndothelial CellsFemaleGlycolatesHydrogelsLactic AcidMicrocirculationNeovascularization, PhysiologicPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerRatsRats, Sprague-DawleyRats, TransgenicSpinal CordSpinal Cord InjuriesStem Cell TransplantationTissue EngineeringTissue ScaffoldsTreatment OutcomeConceptsBlood-spinal cord barrierSpinal cord injuryCord injuryNeural progenitor cellsEndothelial cellsPositive stainingRat hemisection modelEndothelial barrier antigenFunctional vesselsRole of angiogenesisInjury epicenterSimilar coculturesSpinal cordNPC groupHemisection modelEC groupVessel densityLesion controlInjuryNeural regenerationProgenitor cellsAngiogenesisNeural progenitorsSubcutaneous modelCocultureCo-culture of primary neural progenitor and endothelial cells in a macroporous gel promotes stable vascular networks in vivo
Rauch MF, Michaud M, Xu H, Madri JA, Lavik EB. Co-culture of primary neural progenitor and endothelial cells in a macroporous gel promotes stable vascular networks in vivo. Journal Of Biomaterials Science Polymer Edition 2008, 19: 1469-1485. PMID: 18973724, DOI: 10.1163/156856208786140409.Peer-Reviewed Original Research
2006
A macroporous hydrogel for the coculture of neural progenitor and endothelial cells to form functional vascular networks in vivo
Ford MC, Bertram JP, Hynes SR, Michaud M, Li Q, Young M, Segal SS, Madri JA, Lavik EB. A macroporous hydrogel for the coculture of neural progenitor and endothelial cells to form functional vascular networks in vivo. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 2512-2517. PMID: 16473951, PMCID: PMC1413771, DOI: 10.1073/pnas.0506020102.Peer-Reviewed Original Research
2003
Maternal Diabetes: Effects on Embryonic Vascular Development—A Vascular Endothelial Growth Factor-A-mediated Process
Madri JA, Enciso J, Pinter E. Maternal Diabetes: Effects on Embryonic Vascular Development—A Vascular Endothelial Growth Factor-A-mediated Process. Pediatric And Developmental Pathology 2003, 6: 334-341. PMID: 14692647, DOI: 10.1007/s10024-003-5051-9.Peer-Reviewed Original ResearchConceptsEmbryonic lethal phenotypeGrowth factorVascular endothelial growth factorEndothelial growth factorEpithelial-mesenchymal transformationCardiovascular patterningAberrant organogenesisLethal phenotypeVasculogenesis/angiogenesisPhosphorylation stateTargeted mutationsYolk sacMajor congenital malformationsFactor 1Major birth defectsGrowth factor-1OrganogenesisAdhesion moleculesConceptus culturesMaternal diabetesDiabetic miceCardiovascular abnormalitiesVitelline circulationCongenital malformationsBirth defects
2001
Hyperglycemia-Induced Vasculopathy in the Murine Conceptus Is Mediated via Reductions of VEGF-A Expression and VEGF Receptor Activation
Pinter E, Haigh J, Nagy A, Madri J. Hyperglycemia-Induced Vasculopathy in the Murine Conceptus Is Mediated via Reductions of VEGF-A Expression and VEGF Receptor Activation. American Journal Of Pathology 2001, 158: 1199-1206. PMID: 11290536, PMCID: PMC1891927, DOI: 10.1016/s0002-9440(10)64069-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood VesselsEndothelial Growth FactorsFetal DiseasesFetusHyperglycemiaLymphokinesMicePhosphorylationReceptor Protein-Tyrosine KinasesReceptors, Growth FactorReceptors, Vascular Endothelial Growth FactorTime FactorsVascular DiseasesVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsConceptsVEGF receptorsMajor congenital malformationsCongenital cardiovascular abnormalitiesVEGF/VEGF receptorVitelline circulationNovel therapeutic approachesLevels of VEGFReduction of VEGFCause of mortalityDiabetic mothersInsult resultsVEGF levelsCardiovascular abnormalitiesHyperglycemic insultGlucose levelsTherapeutic approachesCongenital malformationsResultant abnormalitiesReceptor activationVEGF receptor activationCardiovascular systemTeratogenic agentsVasculopathyDiabetesConceptus
1999
New paradigms of signaling in the vasculature: ephrins and metalloproteases
Ilan N, Madri J. New paradigms of signaling in the vasculature: ephrins and metalloproteases. Current Opinion In Biotechnology 1999, 10: 536-540. PMID: 10600686, DOI: 10.1016/s0958-1669(99)00026-9.Peer-Reviewed Original ResearchMeSH KeywordsBlood VesselsHydrolysisMembrane ProteinsMetalloendopeptidasesNeovascularization, PhysiologicSignal Transduction
1997
Extracellular matrix modulation of vascular cell behaviour
Madri J. Extracellular matrix modulation of vascular cell behaviour. Transplant Immunology 1997, 5: 179-183. PMID: 9402683, DOI: 10.1016/s0966-3274(97)80035-4.Peer-Reviewed Original Research
1991
Vascular cells respond differentially to transforming growth factors beta 1 and beta 2 in vitro.
Merwin J, Newman W, Beall L, Tucker A, Madri J. Vascular cells respond differentially to transforming growth factors beta 1 and beta 2 in vitro. American Journal Of Pathology 1991, 138: 37-51. PMID: 1846264, PMCID: PMC1886039.Peer-Reviewed Original ResearchConceptsBovine aortic endothelial cellsBovine aortic smooth muscle cellsGrowth factorGrowth factor beta 1Aortic smooth muscle cellsTGF-beta concentrationsSmooth muscle cellsProliferation of BAECsTGF-beta receptorsBovine aortic endothelial cell migrationType IAortic endothelial cellsTGF beta sCell typesMicrovascular endotheliumVascular cell typesReceptor assayMuscle cellsVascular cellsEndothelial cellsBeta 1Endothelial cell migrationBeta 2Angiogenic assaysBASMCs
1989
The Interactions of Vascular Cells with Solid Phase (Matrix) and Soluble Factors
Madri J, Kocher O, Merwin J, Bell L, Yannariello-Brown J. The Interactions of Vascular Cells with Solid Phase (Matrix) and Soluble Factors. Journal Of Cardiovascular Pharmacology 1989, 14: s70-s75. PMID: 2478828, DOI: 10.1097/00005344-198906146-00015.Peer-Reviewed Original ResearchConceptsVascular bedSoluble factorsVascular cellsEndothelial cellsVascular smooth muscle cellsCell populationsSite of injuryMicrovascular endothelial cellsSmooth muscle cellsVessel endothelial cellsLarge vessel endothelial cellsVascular cell populationsVascular injuryIntimal thickeningInjury variesPlatelet factorInjuryMuscle cellsSoft tissueTube formationVessel wallHeterogeneous cell populationsCell typesCellsRepair process
1980
The collagenous components of the subendothelium. Correlation of structure and function.
Madri J, Dreyer B, Pitlick F, Furthmayr H. The collagenous components of the subendothelium. Correlation of structure and function. Laboratory Investigation 1980, 43: 303-15. PMID: 7003251.Peer-Reviewed Original ResearchConceptsCell surfaceEndothelial cell surfaceEndothelial cellsSpecific immunoprecipitation techniquesBiosynthetic incorporationImmunofluorescence microscopyImmunoelectron microscopyImmunoprecipitation techniquesAB2 collagenCellsCollagenous componentsAggregation occursCorrelation of structureCollagen typesImportant roleMonolayer of endotheliumCollagenPlatelet adhesionPlatelet aggregationImportant determinantNonthrombogenic surfaceVascular wallTreesType IVAdhesion