2008
Engineering angiogenesis following spinal cord injury: a coculture of neural progenitor and endothelial cells in a degradable polymer implant leads to an increase in vessel density and formation of the blood–spinal cord barrier
Rauch MF, Hynes SR, Bertram J, Redmond A, Robinson R, Williams C, Xu H, Madri JA, Lavik EB. Engineering angiogenesis following spinal cord injury: a coculture of neural progenitor and endothelial cells in a degradable polymer implant leads to an increase in vessel density and formation of the blood–spinal cord barrier. European Journal Of Neuroscience 2008, 29: 132-145. PMID: 19120441, PMCID: PMC2764251, DOI: 10.1111/j.1460-9568.2008.06567.x.Peer-Reviewed Original ResearchMeSH KeywordsAbsorbable ImplantsAnimalsBlood VesselsBlood-Brain BarrierCells, CulturedCoculture TechniquesDisease Models, AnimalEndothelial CellsFemaleGlycolatesHydrogelsLactic AcidMicrocirculationNeovascularization, PhysiologicPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerRatsRats, Sprague-DawleyRats, TransgenicSpinal CordSpinal Cord InjuriesStem Cell TransplantationTissue EngineeringTissue ScaffoldsTreatment OutcomeConceptsBlood-spinal cord barrierSpinal cord injuryCord injuryNeural progenitor cellsEndothelial cellsPositive stainingRat hemisection modelEndothelial barrier antigenFunctional vesselsRole of angiogenesisInjury epicenterSimilar coculturesSpinal cordNPC groupHemisection modelEC groupVessel densityLesion controlInjuryNeural regenerationProgenitor cellsAngiogenesisNeural progenitorsSubcutaneous modelCoculture
1992
Indomethacin promotes germinal matrix microvessel maturation in the newborn beagle pup.
Ment L, Stewart W, Ardito T, Huang E, Madri J. Indomethacin promotes germinal matrix microvessel maturation in the newborn beagle pup. Stroke 1992, 23: 1132-1137. PMID: 1636188, DOI: 10.1161/01.str.23.8.1132.Peer-Reviewed Original ResearchConceptsNewborn beagle pupsPostnatal day 2Germinal matrixPostnatal ageBeagle pupsIntraventricular hemorrhageVessel densityDay 2Postnatal day 1Laminin depositionMechanism of actionMicrovessel maturationStudy medicationBeta 1 integrinImmunohistochemical studyPostnatal dayDose i.Animal studiesDay 1IndomethacinNewborn pupsHemorrhageBasement membrane depositionBuffered formalinCollagen staining
1991
Beagle pup germinal matrix maturation studies.
Ment L, Stewart W, Ardito T, Madri J. Beagle pup germinal matrix maturation studies. Stroke 1991, 22: 390-395. PMID: 2003309, DOI: 10.1161/01.str.22.3.390.Peer-Reviewed Original ResearchConceptsAlpha-smooth muscle actinIntraventricular hemorrhageDay 1Muscle actinRisk periodGlial fibrillary acidic proteinGerminal matrix vasculatureNewborn beagle pupsPostnatal day 1Postnatal day 4Postnatal day 10Fibrillary acidic proteinGerminal matrix vesselsGerminal matrix tissuePreterm infantsImmunohistochemical studyPerinatal maturationPostnatal dayBeagle pupsVessel densityHemorrhageExtracellular matrix componentsDay 4Day 10Basement membrane proteins