1994
Expression of a functional human complement inhibitor in a transgenic pig as a model for the prevention of xenogeneic hyperacute organ rejection.
Fodor W, Williams B, Matis L, Madri J, Rollins S, Knight J, Velander W, Squinto S. Expression of a functional human complement inhibitor in a transgenic pig as a model for the prevention of xenogeneic hyperacute organ rejection. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 11153-11157. PMID: 7526391, PMCID: PMC45185, DOI: 10.1073/pnas.91.23.11153.Peer-Reviewed Original ResearchConceptsHuman complement inhibitorsHyperacute rejectionComplement inhibitorsAnti-porcine antibodiesTerminal complement inhibitorTransgenic pigsXenogeneic transplantation modelPorcine cell typesHigh-level cell surface expressionVariety of murineXenogeneic complementsXenogeneic organ transplantationGraft failureOrgan rejectionVessel occlusionCell surface expressionHyperacute organ rejectionTransplantation modelOrgan transplantationXenogeneic organsVascular endotheliumTransgenic miceSerum complementAutologous complementTransplantation
1987
The Basement Membrane Underlying the Vascular Endothelium Is Not Thrombogenic: In Vivo and In Vitro Studies with Rabbit and Human Tissue
Buchanan M, Richardson M, Haas T, Hirsh J, Madri J. The Basement Membrane Underlying the Vascular Endothelium Is Not Thrombogenic: In Vivo and In Vitro Studies with Rabbit and Human Tissue. Thrombosis And Haemostasis 1987, 58: 698-704. PMID: 3672420, DOI: 10.1055/s-0038-1645958.Peer-Reviewed Original ResearchConceptsEndothelial cellsPlatelet accumulationAir perfusionBalloon catheter injuryBasement membraneRabbit carotid arteryCatheter strippingCatheter injuryPerfusion injuryHuman endothelial cellsPlatelet reactivityInteraction of plateletsCarotid arteryElectron microscopic examinationVascular endotheliumTransmission electron microscopic examinationPlatelet adhesionCollagen type IInjuryOne hourConflicting resultsMicroscopic examinationSubendotheliumBasement membrane componentsVivo