2006
The roles of nitric oxide in murine cardiovascular development
Nath AK, Madri JA. The roles of nitric oxide in murine cardiovascular development. Developmental Biology 2006, 292: 25-33. PMID: 16442519, DOI: 10.1016/j.ydbio.2005.12.039.Peer-Reviewed Original ResearchConceptsMammalian organ systemsCardiovascular developmentCell contextBiological functionsOrgan system developmentRedox milieuRegulatory roleDiverse arrayRole of NOBiochemical environmentOrgan systemsNitric oxidePathological statesParadoxical actionPotential implicationsRoleReproductionProduction of NOSystem developmentCytoprotectionWide range
2004
Nitric oxide modulates murine yolk sac vasculogenesis and rescues glucose induced vasculopathy
Nath AK, Enciso J, Kuniyasu M, Hao XY, Madri JA, Pinter E. Nitric oxide modulates murine yolk sac vasculogenesis and rescues glucose induced vasculopathy. Development 2004, 131: 2485-2496. PMID: 15128676, DOI: 10.1242/dev.01131.Peer-Reviewed Original ResearchConceptsVascular developmentReactive oxygen speciesYolk sac vasculogenesisMurine yolk sacYolk sacBlood island formationEnvironmental insultsNormal embryonic growthMurine embryo culturePreimplantation embryogenesisAbnormal vascular developmentGenetic manipulationDevelopmental arrestExpression patternsPostimplantation developmentNitric oxideEndodermal layerEmbryonic growthFunctional inactivationHigh glucoseROS productionRole of NOBlastocyst invasionProtein levelsEmbryo culture
1997
Nitric oxide synthase inhibitors attenuate transforming-growth-factor-beta 1-stimulated capillary organization in vitro.
Papapetropoulos A, Desai KM, Rudic RD, Mayer B, Zhang R, Ruiz-Torres MP, García-Cardeña G, Madri JA, Sessa WC. Nitric oxide synthase inhibitors attenuate transforming-growth-factor-beta 1-stimulated capillary organization in vitro. American Journal Of Pathology 1997, 150: 1835-44. PMID: 9137106, PMCID: PMC1858220.Peer-Reviewed Original ResearchConceptsNitric oxideL-NAMETube formationNOS isoformsNitric oxide synthase inhibitorL-nitro-arginine methylesterOxide synthase inhibitorNO donor sodium nitroprussideRole of NOTranscriptase-polymerase chain reactionExcess L-arginineDonor sodium nitroprussideSoluble guanylate cyclaseWestern blot analysisEndothelial cell proliferationNOS blockadeCapillary tube formationEndothelial NOSSodium nitroprussideSynthase inhibitorL-arginineMicrovascular ECsAutocrine productionGuanylate cyclaseCapillary organization