2004
A null mutation of Hhex results in abnormal cardiac development,defective vasculogenesis and elevated Vegfa levels
Hallaq H, Pinter E, Enciso J, McGrath J, Zeiss C, Brueckner M, Madri J, Jacobs HC, Wilson CM, Vasavada H, Jiang X, Bogue CW. A null mutation of Hhex results in abnormal cardiac development,defective vasculogenesis and elevated Vegfa levels. Development 2004, 131: 5197-5209. PMID: 15459110, DOI: 10.1242/dev.01393.Peer-Reviewed Original ResearchConceptsEpithelial-mesenchymal transformationVEGFA levelsVentricular septal defectVascular endothelial growth factorDefective vasculogenesisEndothelial growth factorEndocardial cushionsInhibitor of VEGFVascular developmentTract abnormalitiesSeptal defectSFlt-1Right ventricleNormal liverVentral foregut endodermNormal cardiovascular developmentReceptor 1Abnormal cardiac developmentGrowth factorNull mutationVentral foregutAberrant developmentCompact myocardiumAV explantsE8.5-9.0
2001
Astrocyte-derived VEGF mediates survival and tube stabilization of hypoxic brain microvascular endothelial cells in vitro
Chow J, Ogunshola O, Fan S, Li Y, Ment L, Madri J. Astrocyte-derived VEGF mediates survival and tube stabilization of hypoxic brain microvascular endothelial cells in vitro. Brain Research 2001, 130: 123-132. PMID: 11557101, DOI: 10.1016/s0165-3806(01)00220-6.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornApoptosisAstrocytesCell CommunicationCell Culture TechniquesCell DivisionCell HypoxiaCell SurvivalCoculture TechniquesCollagenEndothelial Growth FactorsEndothelium, VascularGelsHypoxia, BrainLymphokinesMitogen-Activated Protein KinasesPhosphorylationProtein Serine-Threonine KinasesProto-Oncogene ProteinsProto-Oncogene Proteins c-aktRatsVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsConceptsBrain microvascular endothelial cellsChronic sublethal hypoxiaVascular endothelial growth factorHypoxic conditionsNewborn rat astrocytesMicrovascular endothelial cellsEndothelial growth factorDose-dependent mannerEffects of hypoxiaVEGF receptor 1Mild hypoxic conditionsImportance of VEGFRBE4 cellsRat astrocytesAmount of VEGFSublethal hypoxiaReceptor 1MAPK tyrosine phosphorylationEndothelial cellsGrowth factorRobust inductionVEGFTube formationTube stabilizationExogenous VEGF