1997
An in vitro three-dimensional coculture model of cerebral microvascular angiogenesis and differentiation
Ment L, Stewart W, Scaramuzzino D, Madri J. An in vitro three-dimensional coculture model of cerebral microvascular angiogenesis and differentiation. In Vitro Cellular & Developmental Biology - Animal 1997, 33: 684-691. PMID: 9358284, DOI: 10.1007/s11626-997-0126-y.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAstrocytesBrainCell DifferentiationCoculture TechniquesDogsEndothelium, VascularEnzyme ActivationFibronectinsImmunohistochemistryLamininMicrocirculationMicroscopy, ConfocalMicroscopy, FluorescenceModels, BiologicalNeovascularization, PhysiologicRatsRNA, MessengerUrokinase-Type Plasminogen ActivatorConceptsAstrocyte coculturesThree-dimensional cocultureBrain microvascular endothelial cellsNewborn beagle pupsPostnatal day 1Microvascular endothelial cellsNeonatal rat forebrainCell typesPlasminogen activator activityPreterm birthMicrovascular responsesBeagle pupsThree-dimensional coculture modelDay 1Rat forebrainGlial processesEndothelial proliferationMicrovascular angiogenesisEndothelial cellsCoculture modelPlasminogen zymographyOnly low levelsExtracellular matrix componentsTube formationCoculture
1992
Autocrine angiotensin system regulation of bovine aortic endothelial cell migration and plasminogen activator involves modulation of proto-oncogene pp60c-src expression.
Bell L, Luthringer D, Madri J, Warren S. Autocrine angiotensin system regulation of bovine aortic endothelial cell migration and plasminogen activator involves modulation of proto-oncogene pp60c-src expression. Journal Of Clinical Investigation 1992, 89: 315-320. PMID: 1370299, PMCID: PMC442850, DOI: 10.1172/jci115578.Peer-Reviewed Original ResearchMeSH Keywords1-Sarcosine-8-Isoleucine Angiotensin IIAngiotensin IIAngiotensin Receptor AntagonistsAngiotensin-Converting Enzyme InhibitorsAnimalsAortaCattleCell MovementCells, CulturedEnalaprilEndothelium, VascularGene Expression Regulation, ViralLisinoprilPlasminogen ActivatorsProtein KinasesProto-Oncogene Proteins pp60(c-src)Receptors, AngiotensinRNA, MessengerConceptsEndothelial cell migrationC-Src expressionCell migrationC-SrcProto-oncogene c-srcC-Src kinase activityPp60c-src expressionCoding sequenceKinase activityU-PABovine aortic endothelial cell migrationAngiotensin-converting enzyme inhibitor lisinoprilRetroviral vectorsProtein 3Plasminogen activatorStable infectionExpressionDenudation injuryPlasminogen activator activityActivatorActivity 2Cell expressionAngiotensin system inhibitionActivator activityEndothelial cell expression