1994
Modulation of platelet-derived growth factor receptor expression in microvascular endothelial cells during in vitro angiogenesis.
Marx M, Perlmutter R, Madri J. Modulation of platelet-derived growth factor receptor expression in microvascular endothelial cells during in vitro angiogenesis. Journal Of Clinical Investigation 1994, 93: 131-139. PMID: 7506710, PMCID: PMC293745, DOI: 10.1172/jci116936.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAnimalsCell DivisionCells, CulturedElectrophoresis, Polyacrylamide GelEndothelium, VascularEpididymisImmunoblottingKineticsMaleMicrocirculationMolecular WeightNeovascularization, PathologicPlatelet-Derived Growth FactorRatsReceptors, Platelet-Derived Growth FactorRecombinant ProteinsTime FactorsConceptsMicrovascular endothelial cellsEndothelial cellsPDGF receptorReceptor expressionPlatelet-derived growth factor receptor expressionGrowth factor receptor expressionPDGF receptor expressionFactor receptor expressionPDGF receptor alphaReceptor surface expressionEndothelial cell growthNovel therapeutic applicationsCell growthSuramin treatmentProliferative responseEndothelial cell phenotypeReceptor alphaPDGF isoformsPDGF-AAInhibited proliferationReceptor regulationPDGF-BBPDGF-ABAngiogenesisCell proliferation
1993
Spatial organization of the extracellular matrix modulates the expression of PDGF-receptor subunits in mesangial cells
Marx M, Daniel T, Kashgarian M, Madri J. Spatial organization of the extracellular matrix modulates the expression of PDGF-receptor subunits in mesangial cells. Kidney International 1993, 43: 1027-1041. PMID: 8510381, DOI: 10.1038/ki.1993.145.Peer-Reviewed Original ResearchConceptsPDGF receptor subunitsMesangial cell phenotypeCell surfaceExtracellular matrixCell phenotypeExtracellular matrix environmentSpatial organizationPDGF responsivenessPDGF receptor alphaTwo-dimensional cultureMulticellular structuresThree-dimensional cultureMetabolic labelingDifferential expressionQuiescent cellsRat mesangial cell growthCell growthPDGF isoforms AASubunitsMatrix environmentCell proliferationPDGF isoformsReceptor subunitsUltrastructural analysisSurface expression