Independent modulation of enterocyte migration and proliferation by growth factors, matrix proteins, and pharmacologic agents in an in vitro model of mucosal healing.
Basson M, Modlin I, Flynn S, Jena B, Madri J. Independent modulation of enterocyte migration and proliferation by growth factors, matrix proteins, and pharmacologic agents in an in vitro model of mucosal healing. Surgery 1992, 112: 299-307; discussion 307-8. PMID: 1353641.Peer-Reviewed Original ResearchConceptsMucosal healingPharmacologic agentsGrowth factorEGF-stimulated proliferationCaco-2 enterocytesHuman Caco-2 enterocytesInhibited basalAlpha 2 integrin subunitMatrix proteinsEnterocyte migrationCollagen IInhibitor genisteinIntegrin subunitsHealingIndomethacinProliferationTyrosine kinaseEGFLamininBasalGenisteinAltered organizationIndependent modulationHuman enterocyte (Caco-2) migration is modulated in vitro by extracellular matrix composition and epidermal growth factor.
Basson M, Modlin I, Madri J. Human enterocyte (Caco-2) migration is modulated in vitro by extracellular matrix composition and epidermal growth factor. Journal Of Clinical Investigation 1992, 90: 15-23. PMID: 1634605, PMCID: PMC443057, DOI: 10.1172/jci115828.Peer-Reviewed Original ResearchConceptsEpidermal growth factorCaco-2 cellsGrowth factorEGF treatmentEnterocyte migrationHuman colonic cell lineColonic cell lineAlpha 2 subunitIntegrin surface expressionEGF-treated cellsAlpha integrin subunitsCollagen I.Functional antibodiesCell surface receptorsCollagen type IIntegrin expressionAlpha 2Basal migrationCell proliferationSurface expressionCollagen IExtracellular matrix compositionCell linesIntegrin subunitsSurface receptors