Vascular endothelial growth factor mediates reactive angiogenesis in the postnatal developing brain
Ment L, Stewart W, Fronc R, Seashore C, Mahooti S, Scaramuzzino D, Madri J. Vascular endothelial growth factor mediates reactive angiogenesis in the postnatal developing brain. Brain Research 1997, 100: 52-61. PMID: 9174246, DOI: 10.1016/s0165-3806(97)00012-6.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAstrocytesCell DivisionCell HypoxiaCells, CulturedCerebral CortexCoculture TechniquesEndothelial Growth FactorsEndothelium, VascularHypoxia, BrainLymphokinesMicrocirculationNeovascularization, PathologicNeovascularization, PhysiologicRatsRats, Sprague-DawleyRNA, MessengerTranscription, GeneticVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsConceptsVascular endothelial growth factorEndothelial growth factorVEGF protein levelsExperimental ratsSublethal hypoxiaBrain microvascular endothelial cellsEndothelial cellsGrowth factorChronic sublethal hypoxiaProtein levelsAge-matched controlsMicrovascular endothelial cellsHypoxic pupsHRP studyCortical vesselsImmunohistochemical studyVascular densityAddition of VEGFBeagle pupsNewborn ratsReactive angiogenesisAstrocyte culturesThree-dimensional cocultureRat forebrainVEGF protein