2023
CD31 as a probable responding and gate-keeping protein of the blood-brain barrier and the risk of Alzheimer’s disease
Zhang Z, Gan Q, Han J, Tao Q, Qiu W, Madri J. CD31 as a probable responding and gate-keeping protein of the blood-brain barrier and the risk of Alzheimer’s disease. Cerebrovascular And Brain Metabolism Reviews 2023, 43: 1027-1041. PMID: 37051650, PMCID: PMC10291450, DOI: 10.1177/0271678x231170041.Peer-Reviewed Original ResearchConceptsPlatelet endothelial cell adhesion moleculeImmune cellsDisease riskBlood-brain barrier permeabilityMajor genetic risk factorBlood-brain barrierNeuronal cell injuryEndothelial cell adhesion moleculesAlzheimer's disease riskGenetic risk factorsPeripheral inflammationBrain axisAPOE4 carriersAD pathogenesisRisk factorsBarrier permeabilityAD developmentCell adhesion moleculeCell injuryImmune systemAlzheimer's diseaseCD31Transendothelial migrationPotential drug targetsAdhesion molecules
1989
Effect of platelet factors on migration of cultured bovine aortic endothelial and smooth muscle cells.
Bell L, Madri J. Effect of platelet factors on migration of cultured bovine aortic endothelial and smooth muscle cells. Circulation Research 1989, 65: 1057-1065. PMID: 2791219, DOI: 10.1161/01.res.65.4.1057.Peer-Reviewed Original ResearchConceptsSmooth muscle cellsPlatelet-derived growth factorSMC proliferationPlatelet factorEC proliferationMuscle cellsGrowth factorEndothelial cell injuryMechanism of actionVascular injuryVascular diseaseCell injurySMC migrationBovine aortic ECsAortic ECsInjuryNorepinephrineProliferationHistaminePresent studyResponse of ECPhenoxybenzamineKetanserinCellsAtherosclerosis