2009
Proteomic-Based Detection of a Protein Cluster Dysregulated during Cardiovascular Development Identifies Biomarkers of Congenital Heart Defects
Nath AK, Krauthammer M, Li P, Davidov E, Butler LC, Copel J, Katajamaa M, Oresic M, Buhimschi I, Buhimschi C, Snyder M, Madri JA. Proteomic-Based Detection of a Protein Cluster Dysregulated during Cardiovascular Development Identifies Biomarkers of Congenital Heart Defects. PLOS ONE 2009, 4: e4221. PMID: 19156209, PMCID: PMC2626248, DOI: 10.1371/journal.pone.0004221.Peer-Reviewed Original ResearchConceptsCardiovascular developmentMass spectrometry-based proteomicsSpectrometry-based proteomicsNormal cardiovascular developmentAdhesion/migrationHuman CHDsProteomic datasetsHeart developmentProtein clustersMurine embryosProtein pathwayMolecular pathwaysFunctional roleProteinEmbryonic survivalYolk sacProtein levelsIdentifies biomarkersCardiovascular defectsWestern blottingPathwayNovel avenuesEmbryosComplete understandingProtein biomarkers
2006
The roles of nitric oxide in murine cardiovascular development
Nath AK, Madri JA. The roles of nitric oxide in murine cardiovascular development. Developmental Biology 2006, 292: 25-33. PMID: 16442519, DOI: 10.1016/j.ydbio.2005.12.039.Peer-Reviewed Original ResearchConceptsMammalian organ systemsCardiovascular developmentCell contextBiological functionsOrgan system developmentRedox milieuRegulatory roleDiverse arrayRole of NOBiochemical environmentOrgan systemsNitric oxidePathological statesParadoxical actionPotential implicationsRoleReproductionProduction of NOSystem developmentCytoprotectionWide range