2015
Cell–extracellular matrix interactions in oral tumorigenesis: Roles of podoplanin and CD44 and modulation of Hippo pathway
Tsuneki M, Madri J, Saku T. Cell–extracellular matrix interactions in oral tumorigenesis: Roles of podoplanin and CD44 and modulation of Hippo pathway. Journal Of Oral Biosciences 2015, 57: 45-53. DOI: 10.1016/j.job.2015.02.004.Peer-Reviewed Original ResearchCell-extracellular matrix interactionsHippo pathwayExtracellular matrixDynamic reciprocal interactionsMatrix interactionsCell surfaceHyaluronan-rich extracellular matrixMultifunctional transmembrane proteinBasolateral cell surfaceVascular endothelialEndothelial cell survivalAdhesion moleculesStromal cellsVascular endothelial cell survivalTransmembrane proteinMurine hemangioendothelioma cellsTumor cellsSquamous cell carcinoma cellsOral squamous cell carcinoma cellsCell survivalContact inhibitionVE-cadherinTissue architectureTumor survivalIntercellular spaces
1987
Dependence on pH of polarized sorting of secreted proteins
Caplan M, Stow J, Newman A, Madri J, Anderson H, Farquhar M, Palade G, Jamieson J. Dependence on pH of polarized sorting of secreted proteins. Nature 1987, 329: 632-635. PMID: 2821405, DOI: 10.1038/329632a0.Peer-Reviewed Original ResearchConceptsSecretory proteinsMDCK cellsDifferent protein compositionsBasolateral cell surfacePolarized sortingMembrane proteinsBasolateral domainDefault pathwayPlasma membraneAcidic intracellular compartmentsIntracellular compartmentsProtein compositionMembrane componentsCell surfaceBasement membrane componentsProteinSecrete lamininDistinct setsRenal tubule cellsEpithelial cellsActive sortingBasolateral compartmentCellsSecretory productsSpecific regions