2000
Matrix metalloproteinase activity is required for activity-induced angiogenesis in rat skeletal muscle
Haas T, Milkiewicz M, Davis S, Zhou A, Egginton S, Brown M, Madri J, Hudlicka O. Matrix metalloproteinase activity is required for activity-induced angiogenesis in rat skeletal muscle. AJP Heart And Circulatory Physiology 2000, 279: h1540-h1547. PMID: 11009439, DOI: 10.1152/ajpheart.2000.279.4.h1540.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCapillariesCell DivisionDipeptidesElectric StimulationImmunohistochemistryMatrix Metalloproteinase 2Matrix Metalloproteinase InhibitorsMatrix Metalloproteinases, Membrane-AssociatedMetalloendopeptidasesMicroscopy, ElectronMotor ActivityMuscle, SkeletalNeovascularization, PhysiologicProtease InhibitorsRatsRNA, MessengerConceptsMembrane proteinsBasement membrane proteinsEndothelial cell sprout formationRat skeletal muscleSkeletal muscleMatrix metalloproteinasesMembrane type 1Inflammation-mediated angiogenesisPhysiological angiogenesisBasement membraneCell proliferationMMP proteolysisProtein levelsProteolysisSprout formationMajor classesCritical roleProteinMatrix metalloproteinase activityMetalloproteinase activityProliferationAngiogenesisNew capillariesMembraneMMP inhibition
1999
Extracellular Matrix-Driven Matrix Metalloproteinase Production in Endothelial Cells Implications for Angiogenesis
Haas T, Madri J. Extracellular Matrix-Driven Matrix Metalloproteinase Production in Endothelial Cells Implications for Angiogenesis. Trends In Cardiovascular Medicine 1999, 9: 70-77. PMID: 10578520, DOI: 10.1016/s1050-1738(99)00014-6.Peer-Reviewed Original ResearchConceptsInterstitial matrix moleculesCell-extracellular matrix interactionsBasement membrane matrixMatrix metalloproteinasesTranscriptional activationBlood vessel growthMatrix interactionsNew blood vessel growthMatrix moleculesCell surfaceExtracellular matrixMT1-MMPAdjacent cellsCell interactionsMatrix metalloproteinase productionCurrent understandingVessel growthParticular matrix metalloproteinasesEndothelial cell interactionsPotential roleAngiogenesisMetalloproteinase productionBasement membraneMMP-2Signaling
1987
The Basement Membrane Underlying the Vascular Endothelium Is Not Thrombogenic: In Vivo and In Vitro Studies with Rabbit and Human Tissue
Buchanan M, Richardson M, Haas T, Hirsh J, Madri J. The Basement Membrane Underlying the Vascular Endothelium Is Not Thrombogenic: In Vivo and In Vitro Studies with Rabbit and Human Tissue. Thrombosis And Haemostasis 1987, 58: 698-704. PMID: 3672420, DOI: 10.1055/s-0038-1645958.Peer-Reviewed Original ResearchConceptsEndothelial cellsPlatelet accumulationAir perfusionBalloon catheter injuryBasement membraneRabbit carotid arteryCatheter strippingCatheter injuryPerfusion injuryHuman endothelial cellsPlatelet reactivityInteraction of plateletsCarotid arteryElectron microscopic examinationVascular endotheliumTransmission electron microscopic examinationPlatelet adhesionCollagen type IInjuryOne hourConflicting resultsMicroscopic examinationSubendotheliumBasement membrane componentsVivo
1986
Basement membrane as a spatial organizer of polarized epithelia. Exogenous basement membrane reorients pancreatic epithelial tumor cells in vitro.
Ingber DE, Madri JA, Jamieson JD. Basement membrane as a spatial organizer of polarized epithelia. Exogenous basement membrane reorients pancreatic epithelial tumor cells in vitro. American Journal Of Pathology 1986, 122: 129-39. PMID: 3942197, PMCID: PMC1888129.Peer-Reviewed Original ResearchConceptsDistinct membrane domainsEpithelial cell-cell interactionsCell shape changesCell-cell interactionsAcinar tumor cellsMembrane domainsTumor cellsBasement membranePolarized distributionSpatial organizersGolgi complexProtein synthesisIndividual cellsCell surfaceLipid dropletsIntracellular actinPancreatic acinar carcinomaJunctional complexesEpithelial tumor cellsCell contactCytoskeletal alterationsAmniotic basement membraneEpithelial orientationIntact basement membraneZymogen granules
1983
Methods in laboratory investigation. Monoclonal antibodies to type IV collagen: probes for the study of structure and function of basement membranes.
Foellmer H, Madri J, Furthmayr H. Methods in laboratory investigation. Monoclonal antibodies to type IV collagen: probes for the study of structure and function of basement membranes. Laboratory Investigation 1983, 48: 639-49. PMID: 6682465.Peer-Reviewed Original Research
1982
Isolation of a subunit of laminin and its role in molecular structure and tumor cell attachment.
Rao C, Margulies I, Tralka T, Terranova V, Madri J, Liotta L. Isolation of a subunit of laminin and its role in molecular structure and tumor cell attachment. Journal Of Biological Chemistry 1982, 257: 9740-9744. PMID: 7107589, DOI: 10.1016/s0021-9258(18)34135-8.Peer-Reviewed Original ResearchConceptsElectron microscopySubunits of lamininGlobular end regionsBeta subunitLaminin short armsTumor cellsWhole laminin moleculeAlpha subunitSquamous carcinoma cellsHuman squamous carcinoma cellsMicroscopyCell attachmentLaminin moleculeAttachment propertiesCarcinoma cellsTumor cell attachmentBasement membraneLong armAlpha-thrombinLocalization of Collagen Type IV in Basement Membranes by Monoclonal Antibodies
FOELLMER H, MADRI J, WYATT R, FURTHMAYR H. Localization of Collagen Type IV in Basement Membranes by Monoclonal Antibodies. Protides Of The Biological Fluids 1982, 29: 773-776. DOI: 10.1016/b978-0-08-027988-6.50180-4.Peer-Reviewed Original ResearchMonoclonal antibodiesType IV collagenBasement membraneType IVFrozen sectionsNormal human kidneyIV collagenSheep anti-rabbit IgGRabbit anti-mouse IgGBowman's capsuleCollagen type IVThick frozen sectionsHuman kidneyHuman placentaImmunofluorescence stainingAntibodiesKidneySpecific stainingSimilar labeling patternIgGMouse IgGAnti-rabbit IgGMouse EHS tumorStainingCollagen
1980
Ultrastructural localization of fibronectin and laminin in the basement membranes of the murine kidney.
Madri J, Roll F, Furthmayr H, Foidart J. Ultrastructural localization of fibronectin and laminin in the basement membranes of the murine kidney. Journal Of Cell Biology 1980, 86: 682-687. PMID: 6995470, PMCID: PMC2111490, DOI: 10.1083/jcb.86.2.682.Peer-Reviewed Original ResearchConceptsTubular basement membraneMesangial areaBowman's capsuleMesangial matrixBasement membraneFrozen sectionsNormal murine kidneyMurine kidneyAffinity-purified rabbit antibodiesConventional frozen sectionsGlomerular basement membraneSheep anti-rabbit IgGLaminin labellingThick frozen sectionsImmunofluorescence stainingSpecific antibodiesRabbit antibodiesLamina rara internaMesangial cell processesKidneyUltrastructural levelCapsuleAntibodiesAnti-rabbit IgGLamininCollagen polymorphism in the lung An immunochemical study of pulmonary fibrosis
Madri J, Furthmayr H. Collagen polymorphism in the lung An immunochemical study of pulmonary fibrosis. Human Pathology 1980, 11: 353-366. PMID: 6997183, DOI: 10.1016/s0046-8177(80)80031-1.Peer-Reviewed Original ResearchConceptsPerivascular localizationLung samplesFibrotic human lungSmooth muscle cell proliferationType IIndirect immunofluorescence techniqueLung type IMuscle cell proliferationType VType IIICapillary basement membranePulmonary fibrosisFibrotic processAlveolar septaType IV collagenImmunofluorescence techniqueHuman lungCell proliferationInterstitiumMarked increaseType IVBasement membraneImmunochemical studiesIrregular localizationIV collagen
1979
Isolation and tissue localization of type AB2 collagen from normal lung parenchyma.
Madri J, Furthmayr H. Isolation and tissue localization of type AB2 collagen from normal lung parenchyma. American Journal Of Pathology 1979, 94: 323-31. PMID: 371411, PMCID: PMC2042247.Peer-Reviewed Original ResearchConceptsNormal lung parenchymaLung parenchymaAffinity-purified rabbit antibodiesLung tissuePassive hemagglutinationPlacental membranesChorionic membraneAB2 collagenTissue localizationIndirect immunofluorescence microscopyRabbit antibodiesBasement membraneChain ratioParenchymaImmunofluorescence microscopyCollagenPolyacrylamide gel electrophoresisGel electrophoresisAlpha ADifferential salt extractionCell surface