2024
Hepatitis Delta Virus Testing, Prevalence, and Liver-Related Outcomes Among U.S. Veterans with Chronic Hepatitis B
Wong R, Yang Z, Jou J, John B, Lim J, Cheung R. Hepatitis Delta Virus Testing, Prevalence, and Liver-Related Outcomes Among U.S. Veterans with Chronic Hepatitis B. Gastro Hep Advances 2024 DOI: 10.1016/j.gastha.2024.10.015.Peer-Reviewed Original ResearchChronic hepatitis B patientsChronic hepatitis BLiver-related outcomesHepatic decompensationHepatitis delta virusCohort of U.S. veteransNational cohortU.S. veteransRisk of cirrhosisIncidence of cirrhosisPositive patientsHDV infectionHepatitis BEvaluate incidenceHepatocellular carcinomaCirrhosisPatientsDecompensationVirus testingPropensity scoreHepatitisDelta virusNelson-Aalen methodDiagnosisOutcomesOutcomes of a 1‐Year Pilot Study Implementing Universal Hepatitis Delta Virus Testing Among Veterans With Chronic Hepatitis B
Wong R, Liao M, Chen Y, Kwan M, Lee J, Jou J, Lim J, Cheung R. Outcomes of a 1‐Year Pilot Study Implementing Universal Hepatitis Delta Virus Testing Among Veterans With Chronic Hepatitis B. Journal Of Viral Hepatitis 2024, 31: 768-770. PMID: 39101377, DOI: 10.1111/jvh.13992.Peer-Reviewed Original ResearchChronic hepatitis BAnti-HDVRNA testingHepatitis delta virusVeterans Affairs Health SystemUniversal testing approachAnti-HDV-positive patientsPilot studyChronic hepatitis B patientsProspective cohort studyHDV-RNA testsAnti-HDV antibodiesConsecutive CHB patientsRisk-based testingHealth systemDetectable HDV RNAChi-square testUS veteransDrug use historyCohort studyCirrhosis statusCHB patientsConsecutive adultsNo significant differenceAb positivityAssociation of Baseline Hepatitis B Virus DNA and On-Treatment Risk of Cirrhosis and Hepatocellular Carcinoma
Yang Z, Cheung R, Jou J, Lim J, Lim Y, Wong R. Association of Baseline Hepatitis B Virus DNA and On-Treatment Risk of Cirrhosis and Hepatocellular Carcinoma. Gastroenterology Research 2024, 17: 109-115. PMID: 38993547, PMCID: PMC11236339, DOI: 10.14740/gr1735.Peer-Reviewed Original ResearchBaseline HBV DNARisk of hepatocellular carcinomaChronic hepatitis BRisk of cirrhosisNon-cirrhotic chronic hepatitis BHepatitis B virus DNAHBV DNAHepatocellular carcinomaHepatitis B virusCHB patientsPropensity score weightingAntiviral therapyAssociated with higher risk of hepatocellular carcinomaHigh risk of hepatocellular carcinomaNon-cirrhotic CHB patientsCohort of CHB patientsLevels of hepatitis B virusContinuous antiviral therapyHigh HBV DNANon-Asian cohortModerate levelsAssociated with higher riskScore weightingB virus DNACox proportional hazards modelsAdvances in discovery of novel investigational agents for functional cure of chronic hepatitis B: A comprehensive review of phases II and III therapeutic agents
Lam R, Lim J. Advances in discovery of novel investigational agents for functional cure of chronic hepatitis B: A comprehensive review of phases II and III therapeutic agents. World Journal Of Hepatology 2024, 16: 331-343. PMID: 38577537, PMCID: PMC10989302, DOI: 10.4254/wjh.v16.i3.331.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsFunctional cure of chronic hepatitis BCure of chronic hepatitis BNovel investigational agentsChronic hepatitis BFunctional cureHepatitis B virusInvestigational agentsHepatitis BSuppression of HBV DNARisk of liver complicationsChronic hepatitis B virusAssociated with significant morbidityToll-like receptor agonistsOral nucleos(t)ide analoguesHepatitis B surface antigenB surface antigenLong-term treatmentAssociated with higher ratesMortality due to cirrhosisCheckpoint inhibitorsNucleos(t)ide analoguesVirologic suppressionPhase IIAntiviral regimensIII trials
2023
554 RISK OF CIRRHOSIS AND HEPATOCELLULAR CARCINOMA ACROSS A GRADIENT OF BASELINE HEPATITIS B VIRAL LOAD AMONG A NATIONAL COHORT OF PREDOMINANTLY NON-ASIAN VETERANS WITH CHRONIC HEPATITIS B IN THE UNITED STATES
Yang Z, Cheung R, Lim J, Jou J, Wong R. 554 RISK OF CIRRHOSIS AND HEPATOCELLULAR CARCINOMA ACROSS A GRADIENT OF BASELINE HEPATITIS B VIRAL LOAD AMONG A NATIONAL COHORT OF PREDOMINANTLY NON-ASIAN VETERANS WITH CHRONIC HEPATITIS B IN THE UNITED STATES. Gastroenterology 2023, 164: s-1254. DOI: 10.1016/s0016-5085(23)03914-8.Peer-Reviewed Original Research
2020
Clinical Outcome Event Adjudication in a 10-Year Prospective Study of Nucleos(t)ide Analogue Therapy for Chronic Hepatitis B
Lim JK, Chang AY, Zaman A, Martin P, Fernandez-Rodriguez CM, Korkmaz M, Rossi S, Ford JM, Noonan T, Cooney E, Navarro V, Colombato L. Clinical Outcome Event Adjudication in a 10-Year Prospective Study of Nucleos(t)ide Analogue Therapy for Chronic Hepatitis B. Journal Of Clinical And Translational Hepatology 2020, 8: 377-384. PMID: 33447520, PMCID: PMC7782110, DOI: 10.14218/jcth.2020.00039.Peer-Reviewed Original ResearchClinical outcome eventsHepatocellular carcinomaDiagnostic criteriaChronic hepatitis B virus infectionHepatitis B virus infectionPrimary study outcome measureHBV disease progressionNon-HCC malignanciesChronic hepatitis BB virus infectionStudy outcome measuresDisease progression eventsEvent adjudication committeePotential adverse effectsRandomized therapyAnalogue therapyHepatitis BProspective studyAdjudicated diagnosisAdjudication committeeMalignant neoplasmsDisease progressionEvent adjudicationOutcome eventsVirus infection
2018
Healthcare resource utilization and costs by disease severity in an insured national sample of US patients with chronic hepatitis B
Nguyen MH, Ozbay AB, Liou I, Meyer N, Gordon SC, Dusheiko G, Lim JK. Healthcare resource utilization and costs by disease severity in an insured national sample of US patients with chronic hepatitis B. Journal Of Hepatology 2018, 70: 24-32. PMID: 30287341, DOI: 10.1016/j.jhep.2018.09.021.Peer-Reviewed Original ResearchConceptsAdvanced liver diseaseCompensated liver diseaseLiver diseaseDisease severityCause inpatientLiver transplantHepatitis BHealthcare utilizationHepatocellular carcinomaHigh emergency department (ED) utilizationHighest mean annual costCause inpatient admissionsChronic hepatitis BDisease statesHealthcare resource utilizationLiver disease groupEmergency department utilizationEmergency room visitsHepatocellular carcinoma groupProgressive disease statesPharmaceutical utilizationMean annual costLiver disease statesProgressive diseaseHepatitis B.An expert consensus for the management of chronic hepatitis B in Asian Americans
Tong MJ, Pan CQ, Han S, Lu D, Raman S, Hu K, Lim JK, Hann HW, Min AD. An expert consensus for the management of chronic hepatitis B in Asian Americans. Alimentary Pharmacology & Therapeutics 2018, 47: 1181-1200. PMID: 29479728, PMCID: PMC5900913, DOI: 10.1111/apt.14577.Peer-Reviewed Original ResearchConceptsChronic hepatitis BAnti-viral therapyHepatocellular carcinomaHepatitis BHBV DNAPregnant womenBasal core promoter mutationsNegative chronic hepatitis BHepatitis B virus infectionAsian American physiciansLiver related deathManagement of HBVDetectable HBV DNAHBeAg-negative patientsHBsAg-positive patientsHBV DNA levelsNormal ALT levelsB virus infectionCore promoter mutationsHBsAg carrier rateLife-long surveillanceContrast CT scanAbdominal ultrasound examinationAlpha-fetoprotein testingAsian American patients