Joseph Guarnaccia, MD
Medical Services ProviderCards
Additional Titles
Assistant Clinical Professor
Consulting Neurologist and Research Physician, Yale Stress Center
About
Titles
Medical Services Provider
Assistant Clinical Professor; Consulting Neurologist and Research Physician, Yale Stress Center
Biography
Joseph Guarnaccia, MD, is a board-certified neurologist in practice for more than 30 years, having completed his residency at the Yale School of Medicine, Department of Neurology in 1993. He was Assistant Professor and Director of the Yale Multiple Sclerosis Treatment Program at Yale until 2000 when he left to establish two multiple sclerosis treatment centers in Derby, CT and Warwick, RI, which he continues to operate. Dr. Guarnaccia has collaborated with the Yale Stress Center on multiple projects including assessing the effects of mindfulness meditation to address insomnia in patients with multiple sclerosis, testing and development of cannabis compounds in the treatment of chronic pain in patients with and without multiple sclerosis, as well as those with opioid prescription use and misuse. He has also worked on Stress Center Studies involving several experimental and clinical outcomes such as stress biological effects on food reward, alcohol and drug craving, and in clinical trials of alcohol use disorder and substance use disorder treatments.
Appointments
Education & Training
- MD
- University of Oklahoma (1987)
Board Certifications
Neurology
- Certification Organization
- AB of Psychiatry and Neurology
- Original Certification Date
- 1995
Internal Medicine
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 1990
Research
Research at a Glance
Yale Co-Authors
Publications Timeline
Stephen Waxman, MD, PhD
Publications
2006
IM interferon beta-1a delays definite multiple sclerosis 5 years after a first demyelinating event.
Kinkel RP, Kollman C, O'Connor P, Murray TJ, Simon J, Arnold D, Bakshi R, Weinstock-Gutman B, Brod S, Cooper J, Duquette P, Eggenberger E, Felton W, Fox R, Freedman M, Galetta S, Goodman A, Guarnaccia J, Hashimoto S, Horowitz S, Javerbaum J, Kasper L, Kaufman M, Kerson L, Mass M, Rammohan K, Reiss M, Rolak L, Rose J, Scott T, Selhorst J, Shin R, Smith C, Stuart W, Thurston S, Wall M. IM interferon beta-1a delays definite multiple sclerosis 5 years after a first demyelinating event. Neurology 2006, 66: 678-84. PMID: 16436649, DOI: 10.1212/01.wnl.0000200778.65597.ae.Peer-Reviewed Original Research
2000
Sustained clinical benefits of glatiramer acetate in relapsing multiple sclerosis patients observed for 6 years
Johnson K, Brooks B, Ford C, Goodman A, Guarnaccia J, Lisak R, Myers L, Panitch H, Pruitt A, Rose J, Kachuck N, Wolinsky J. Sustained clinical benefits of glatiramer acetate in relapsing multiple sclerosis patients observed for 6 years. Multiple Sclerosis Journal 2000, 6: 255-266. PMID: 10962546, DOI: 10.1177/135245850000600407.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsExpanded Disability Status ScaleOpen-label phaseOpen-label studyAccumulation of disabilityDaily subcutaneous injectionsGlatiramer acetateRelapse rateMultiple sclerosisSubcutaneous injectionRelapsing-remitting multiple sclerosisMean annual relapse rateDouble-blind cohortDouble-blind phaseSustained clinical benefitDouble-blind studyDisability Status ScaleAnnual relapse rateMultiple sclerosis patientsSclerosis patientsClinical benefitStatus ScaleSustained efficacyPatientsActive drugGlatiramerSustained clinical benefits of glatiramer acetate in relapsing multiple sclerosis patients observed for 6 years
Johnson K, Brooks B, Ford C, Goodman A, Guarnaccia J, Lisak R, Myers L, Panitch H, Pruitt A, Rose J, Kachuck N, Wolinsky J. Sustained clinical benefits of glatiramer acetate in relapsing multiple sclerosis patients observed for 6 years. Multiple Sclerosis Journal 2000, 6: 255-266. DOI: 10.1191/135245800678827806.Peer-Reviewed Original ResearchCitationsAltmetric
1997
Modified total lymphoid irradiation and low dose corticosteroids in progressive multiple sclerosis
Cook S, Devereux C, Troiano R, Wolansky L, Guarnaccia J, Haffty B, Bansil S, Goldstein J, Sheffet A, Zito G, Jotkowitz A, Boos J, Dowling P, Rohowsky-Kochan C, Volmer T. Modified total lymphoid irradiation and low dose corticosteroids in progressive multiple sclerosis. Journal Of The Neurological Sciences 1997, 152: 172-181. PMID: 9415539, DOI: 10.1016/s0022-510x(97)00189-5.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsTotal lymphoid irradiationMultiple sclerosisLymphoid irradiationDuration of MSExpanded Disability Status ScaleProgressive formKaplan-Meier product-limit survival analysisLow-dose corticosteroidsLow-dose prednisoneProgressive multiple sclerosisPrimary study endpointDisability Status ScaleProduct-limit survival analysisDose corticosteroidsDose prednisoneIntravenous methylprednisolonePrednisone therapyTLI groupTLI patientsSystemic immunosuppressionPatient ageStudy endpointStudy entrySham groupStatus Scale4-31-01 Total lymphoid irradiation and low dose corticosteroids in progressive MS
Cook S, Devereux C, Troiano R, Wolansky L, Guarnaccia J, Haffty B, Bansil S, Goldstein J, Sheffet A, Zito G, Jotkowitz A, Boos J, Dowling P, Rohowsky-Kochan C, Volmer T. 4-31-01 Total lymphoid irradiation and low dose corticosteroids in progressive MS. Journal Of The Neurological Sciences 1997, 150: s248. DOI: 10.1016/s0022-510x(97)86092-3.Peer-Reviewed Original Research
1993
Painless aortic dissection presenting as a progressive myelopathy
Holloway S, Fayad P, Kalb R, Guarnaccia J, Waxman S. Painless aortic dissection presenting as a progressive myelopathy. Journal Of The Neurological Sciences 1993, 120: 141-144. PMID: 8138802, DOI: 10.1016/0022-510x(93)90265-z.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPainless aortic dissectionAortic dissectionProgressive myelopathyCentral nervous system ischemiaSpinal cord syndromeThoracic aortic dissectionAbsence of painThoracic vertebral bodyMagnetic resonance imagingTransverse myelopathyCord syndromeNeurologic deficitsNeurologic symptomsIschemic changesEarly recognitionSpinal cordDifferential diagnosisNew therapiesVertebral bodyResonance imagingMyelopathyThoracic vertebraeDissectionPainIschemia