2008
Endothelial dysfunction in heart failure identifies responders to cardiac resynchronization therapy
Akar JG, Al-Chekakie MO, Fugate T, Moran L, Froloshki B, Varma N, Santucci P, Wilber DJ, Matsumura ME. Endothelial dysfunction in heart failure identifies responders to cardiac resynchronization therapy. Heart Rhythm 2008, 5: 1229-1235. PMID: 18774094, DOI: 10.1016/j.hrthm.2008.05.027.Peer-Reviewed Original ResearchConceptsCardiac resynchronization therapyFlow-mediated dilationBaseline flow-mediated dilationBaseline endothelial dysfunctionAdditive prognostic valueEndothelial dysfunctionCRT respondersWalk distanceResynchronization therapyPrognostic valueBrachial artery flow-mediated dilationArtery flow-mediated dilationBaseline functional capacityEndothelial function assessmentHeart failure mortalityHeart failure outcomesLikelihood of responseLogistic regression analysisQuality of lifeCurrent selection criteriaEndothelial functionHeart failureQRS durationCurrent guidelinesFunction assessment
2007
Presence of asymmetric dimethylarginine gradients across high-grade lesions in patients with coronary artery disease
Joyal D, Leya F, Al-Chekakie M, Arab D, Dieter RS, Morshedi-Meibodi A, Lewis B, Steen L, Fareed J, Hoppenstead D, Akar JG. Presence of asymmetric dimethylarginine gradients across high-grade lesions in patients with coronary artery disease. Coronary Artery Disease 2007, 18: 471-475. PMID: 17700219, DOI: 10.1097/mca.0b013e32818be79c.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionCoronary interventionCoronary lesionsAsymmetric dimethylarginineEndothelial dysfunctionAsymmetric dimethylarginine accumulationAsymmetric dimethylarginine levelsGeneralized endothelial dysfunctionPeripheral venous siteSystemic venous levelsAsymmetric dimethylarginine concentrationsCoronary artery diseaseHigh-grade lesionsNitric oxide synthaseLevels 24 hDimethylarginine levelsDimethylarginine concentrationsCoronary ostiumArtery diseaseSystemic markersVenous levelsCoronary bedFocal injuryOxide synthaseVenous sites