2024
Observational study protocol for an arrhythmia notification feature
Kumar S, Weinstein J, Melchinger H, Smith A, Capodilupo E, Akar J, Garg K, O’Connor K, Staunton M, Martin M, Akhlaghi N, Edeh O, Perez S, Lee V, Lee K, Wilson F. Observational study protocol for an arrhythmia notification feature. BMJ Open 2024, 14: e075110. PMID: 38830741, PMCID: PMC11149124, DOI: 10.1136/bmjopen-2023-075110.Peer-Reviewed Original ResearchConceptsAtrial fibrillationInstitution of appropriate treatmentGold standardClinical research journalsAssessment of risk factorsObservational study protocolRecruited participantsEthics BoardGeneral populationDiagnosed AFHealthy controlsPrimary outcomeAppropriate treatmentStudy protocolRisk factorsConsent documentsWHOOP strapParticipantsArrhythmiasDetect AFWearable technology
2022
Sex-based differences in atrial fibrillation ablation adverse events
Mszar R, Friedman D, Ong E, Du C, Wang Y, Zeitler E, Cunningham S, Akar J, Curtis J, Freeman J. Sex-based differences in atrial fibrillation ablation adverse events. Heart 2022, 109: 595-605. PMID: 36104219, DOI: 10.1136/heartjnl-2022-321192.Peer-Reviewed Original ResearchConceptsAcute pulmonary vein isolationAdverse eventsPulmonary vein isolationAtrial fibrillationHigh riskSex-based differencesVein isolationCatheter ablationFemale sexLarge prospective registryHospital adverse eventsMajor adverse eventsObservational cohort studyPhrenic nerve damageAF ablation proceduresQuality of lifeAblation RegistryMore comorbiditiesProspective registryAF ablationCohort studyPericardial effusionNerve damagePatient sexVascular injury
2018
Ventricular Fibrillation Conversion Testing After Implantation of a Subcutaneous Implantable Cardioverter Defibrillator
Friedman DJ, Parzynski CS, Heist EK, Russo AM, Akar JG, Freeman JV, Curtis JP, Al-Khatib SM. Ventricular Fibrillation Conversion Testing After Implantation of a Subcutaneous Implantable Cardioverter Defibrillator. Circulation 2018, 137: 2463-2477. PMID: 29463509, PMCID: PMC5988932, DOI: 10.1161/circulationaha.117.032167.Peer-Reviewed Original ResearchConceptsImplantable cardioverter defibrillatorS-ICD implantationLogistic regression analysisInhospital complicationsPatient characteristicsCT testingS-ICDsCardioverter defibrillatorConversion testingPrior implantable cardioverter defibrillatorHigher body mass indexMultivariable logistic regression analysisLarger body surface areaSubcutaneous implantable cardioverter defibrillatorTransvenous implantable cardioverter defibrillatorInhospital adverse eventsLow ejection fractionAvailable patient characteristicsBody mass indexBody surface areaFirst-time recipientsMaximum device outputRegression analysisPredictors of useInsufficient safety margin
2017
Deleterious protein‐altering mutations in the SCN10A voltage‐gated sodium channel gene are associated with prolonged QT
Ziki M, Seidelmann SB, Smith E, Atteya G, Jiang Y, Fernandes RG, Marieb MA, Akar JG, Mani A. Deleterious protein‐altering mutations in the SCN10A voltage‐gated sodium channel gene are associated with prolonged QT. Clinical Genetics 2017, 93: 741-751. PMID: 28407228, PMCID: PMC5640462, DOI: 10.1111/cge.13036.Peer-Reviewed Original ResearchConceptsLong QT syndromeSCN10A mutationsWhole-exome sequencingVoltage-gated sodium channel geneCongenital long QT syndromeHistory of palpitationsQT prolonging medicationsLife-threatening complicationsIdiopathic long QT syndromeProtein-altering mutationsSodium channel geneConfirmatory Sanger sequencingMutation burden analysisGenetic programAtrial fibrillationIdentifiable causeProlonged QTChannel genesMutation carriersArrhythmia genesQT syndromeGenesLQTS genesFrameshift mutationGenetic causeApplication of Whole Exome Sequencing in the Clinical Diagnosis and Management of Inherited Cardiovascular Diseases in Adults
Seidelmann SB, Smith E, Subrahmanyan L, Dykas D, Abou Ziki MD, Azari B, Hannah-Shmouni F, Jiang Y, Akar JG, Marieb M, Jacoby D, Bale AE, Lifton RP, Mani A. Application of Whole Exome Sequencing in the Clinical Diagnosis and Management of Inherited Cardiovascular Diseases in Adults. Circulation Genomic And Precision Medicine 2017, 10: e001573. PMID: 28087566, PMCID: PMC5245580, DOI: 10.1161/circgenetics.116.001573.Peer-Reviewed Original ResearchConceptsWhole-exome sequencingSudden cardiac deathCardiovascular diseaseClinical diagnosisExome sequencingCardiac deathInherited cardiovascular diseaseCentre of careNovel candidate genesValuable screening toolAdult patientsRisk stratificationPrimary insultCardiac functionGenetic testingScreening toolDiagnosisCVD genesGenetic causeCardiovascular geneticsGenetic panelSuccess rateExome databasesPotential disease associationsPatients
2015
Use of Remote Monitoring Is Associated With Lower Risk of Adverse Outcomes Among Patients With Implanted Cardiac Defibrillators
Akar JG, Bao H, Jones PW, Wang Y, Varosy PD, Masoudi FA, Stein KM, Saxon LA, Normand SL, Curtis JP. Use of Remote Monitoring Is Associated With Lower Risk of Adverse Outcomes Among Patients With Implanted Cardiac Defibrillators. Circulation Arrhythmia And Electrophysiology 2015, 8: 1173-1180. PMID: 26092577, DOI: 10.1161/circep.114.003030.Peer-Reviewed Original ResearchConceptsImplantable cardioverter defibrillatorInitial implantable cardioverter defibrillatorCause mortalityLower riskAdverse outcomesNational Cardiovascular Data Registry ICD RegistryRemote patient monitoringSocial Security Death Master FileCause rehospitalization rateRisk of rehospitalizationImplanted cardiac defibrillatorsDeath Master FileCardiomyopathy pathogenesisCause rehospitalizationICD RegistryRehospitalization ratesMultivariable analysisStudy cohortVital statusService patientsCardioverter defibrillatorCox modelMedicare populationMedicare feePatients
2009
Electroanatomic mapping of postpacing intervals clarifies the complete active circuit and variants in atrial flutter
Santucci PA, Varma N, Cytron J, Akar JG, Wilber DJ, Chekakie M, Brysiewicz N. Electroanatomic mapping of postpacing intervals clarifies the complete active circuit and variants in atrial flutter. Heart Rhythm 2009, 6: 1586-1595. PMID: 19879536, DOI: 10.1016/j.hrthm.2009.08.010.Peer-Reviewed Original ResearchConceptsTricuspid annulusAtrial flutterIsthmus-dependent atrial flutterFlutter cycle lengthPosterior borderTypical atrial flutterRight atrial appendageEntire right atriumFlutter circuitAtrial appendageRight atriumVena cavaElectroanatomic mappingElectroanatomic mapsOblique courseCycle lengthPatientsSimilar activationActivation mappingAnteriorFlutterActivationIntervalCavaAtriumProspective Study of Cardiac Sarcoid Mimicking Arrhythmogenic Right Ventricular Dysplasia
VASAIWALA SC, FINN C, DELPRIORE J, LEYA F, GAGERMEIER J, AKAR JG, SANTUCCI P, DAJANI K, BOVA D, PICKEN MM, BASSO C, MARCUS F, WILBER DJ. Prospective Study of Cardiac Sarcoid Mimicking Arrhythmogenic Right Ventricular Dysplasia. Journal Of Cardiovascular Electrophysiology 2009, 20: 473-476. PMID: 19017339, DOI: 10.1111/j.1540-8167.2008.01351.x.Peer-Reviewed Original ResearchConceptsARVD/CLeft ventricular dysfunctionARVD/C.Cardiac sarcoidMagnetic resonance imagingVentricular dysfunctionProspective studyVentricular arrhythmiasArrhythmogenic right ventricular dysplasia/cardiomyopathyRight ventricular dysplasia/cardiomyopathyDefinite ARVD/CVentricular dysplasia/cardiomyopathyLeft bundle branch blockInternational Task Force criteriaTask Force criteriaBundle branch blockChest X-rayProbable ARVD/CBiopsy consistentRV functionClinical predictorsConsecutive patientsClinical featuresClinical presentationHistological findings
2007
Surface Electrocardiographic Patterns and Electrophysiologic Characteristics of Atrial Flutter Following Modified Radiofrequency MAZE Procedures
AKAR JG, AL‐CHEKAKIE M, HAI A, BRYSIEWICZ N, PORTER M, VARMA N, SANTUCCI P, WILBER DJ. Surface Electrocardiographic Patterns and Electrophysiologic Characteristics of Atrial Flutter Following Modified Radiofrequency MAZE Procedures. Journal Of Cardiovascular Electrophysiology 2007, 18: 349-355. PMID: 17394449, DOI: 10.1111/j.1540-8167.2007.00761.x.Peer-Reviewed Original ResearchConceptsCavo-tricuspid isthmusIsthmus ablationAtrial flutterElectrophysiological characteristicsElectrophysiological studiesECG appearanceCox maze III procedureIsthmus-dependent right atrial flutterRadiofrequency maze procedureSurface electrocardiographic patternsMitral isthmus ablationRight atrial flutterDiagnostic electrophysiological studyShorter cycle lengthsLA flutterPostoperative arrhythmiasRadiofrequency mazeCardiac surgeryConsecutive patientsAtrial circuitsAtrial fibrillationElectrophysiologic characteristicsSinus rhythmSurgical lesionsElectrocardiographic pattern
2006
Idiopathic Epicardial Left Ventricular Tachycardia Originating Remote From the Sinus of Valsalva
Daniels DV, Lu YY, Morton JB, Santucci PA, Akar JG, Green A, Wilber DJ. Idiopathic Epicardial Left Ventricular Tachycardia Originating Remote From the Sinus of Valsalva. Circulation 2006, 113: 1659-1666. PMID: 16567566, DOI: 10.1161/circulationaha.105.611640.Peer-Reviewed Original ResearchConceptsIdiopathic ventricular tachycardiaMaximum deflection indexVentricular tachycardiaEpicardial ventricular tachycardiaDirect surgical ablationSinus of ValsalvaLeft ventricular epicardiumDeflection indexSite of originUnsuccessful ablationAortic sinusVenous mappingCatheter ablationOccasional patientSurgical ablationCoronary veinVT inductionTranspericardial approachVentricular sitesEndocardial activationEpicardial mappingPerivascular sitesECG patternVentricular endocardiumAnatomic constraints
2005
Chagas myocarditis and syncope.
Patel RA, DiMarco JP, Akar JG, Voros S, Kramer CM. Chagas myocarditis and syncope. Journal Of Cardiovascular Magnetic Resonance 2005, 7: 685-8. PMID: 16136859, DOI: 10.1081/jcmr-65627.Peer-Reviewed Original Research
2001
Tachycardia with Atrioventricular Dissociation after Surgery for Single Ventricle
AKAR J, DIMARCO J. Tachycardia with Atrioventricular Dissociation after Surgery for Single Ventricle. Journal Of Cardiovascular Electrophysiology 2001, 12: 1092-1093. PMID: 11573704, DOI: 10.1046/j.1540-8167.2001.01092.x.Peer-Reviewed Original ResearchCoexistence of type I atrial flutter and intra-atrial re-entrant tachycardia in patients with surgically corrected congenital heart disease
Akar J, Kok L, Haines D, DiMarco J, Mounsey J. Coexistence of type I atrial flutter and intra-atrial re-entrant tachycardia in patients with surgically corrected congenital heart disease. Journal Of The American College Of Cardiology 2001, 38: 377-384. PMID: 11499727, DOI: 10.1016/s0735-1097(01)01392-4.Peer-Reviewed Original ResearchConceptsIntra-atrial re-entrant tachycardiaIsthmus-dependent atrial flutterCongenital heart diseaseRe-entrant tachycardiaAtrial flutterHeart diseaseType I atrial flutterSurface electrocardiogramInferior vena cavaSlow conduction zoneRe-entrant tachyarrhythmiasLateral right atriumAtriotomy scarCoexistent arrhythmiaIART recurrenceConsecutive patientsAtrial tachyarrhythmiasProcedural complicationsSupraventricular tachyarrhythmiasFurther recurrenceSuccessful ablationRight atriumVena cavaSurgical correctionEntrainment mapping