2010
Response to Cardiac Resynchronization in Heart Failure: Just Go With the Myocardial Blood Flow?
AKAR JG. Response to Cardiac Resynchronization in Heart Failure: Just Go With the Myocardial Blood Flow? Journal Of Cardiovascular Electrophysiology 2010, 21: 1240-1241. PMID: 20662980, DOI: 10.1111/j.1540-8167.2010.01840.x.Peer-Reviewed Original Research
2009
Multicenter randomized study of anticoagulation guided by remote rhythm monitoring in patients with implantable cardioverter-defibrillator and CRT-D devices: Rationale, design, and clinical characteristics of the initially enrolled cohort The IMPACT study
Ip J, Waldo AL, Lip GY, Rothwell PM, Martin DT, Bersohn MM, Choucair WK, Akar JG, Wathen MS, Rohani P, Halperin JL, Investigators F. Multicenter randomized study of anticoagulation guided by remote rhythm monitoring in patients with implantable cardioverter-defibrillator and CRT-D devices: Rationale, design, and clinical characteristics of the initially enrolled cohort The IMPACT study. American Heart Journal 2009, 158: 364-370.e1. PMID: 19699858, DOI: 10.1016/j.ahj.2009.07.002.Peer-Reviewed Original ResearchConceptsAtrial high-rate episodesRisk of strokeAnticoagulant therapyAtrial fibrillationAtrial flutterCardiac resynchronization therapy-defibrillator deviceConventional clinical managementRemote rhythm monitoringStudies of anticoagulationRate of strokeOral anticoagulant therapyHigh-rate episodesAdditional risk factorsCRT-D devicesStroke risk stratificationCommon cardiac arrhythmiaAHRE burdenElectrocardiographic documentationMajor bleedingSystemic embolismProphylactic therapyClinical characteristicsStroke riskAnticoagulation decisionsClinical featuresElectroanatomic mapping of postpacing intervals clarifies the complete active circuit and variants in atrial flutter
Santucci PA, Varma N, Cytron J, Akar JG, Wilber DJ, Al Chekakie M, Brysiewicz N. Electroanatomic mapping of postpacing intervals clarifies the complete active circuit and variants in atrial flutter. Heart Rhythm 2009, 6: 1586-1595. PMID: 19879536, DOI: 10.1016/j.hrthm.2009.08.010.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAtrial FlutterBody Surface Potential MappingCardiac Pacing, ArtificialFemaleHumansMaleMiddle AgedPacemaker, ArtificialConceptsTricuspid annulusAtrial flutterIsthmus-dependent atrial flutterFlutter cycle lengthPosterior borderTypical atrial flutterRight atrial appendageEntire right atriumFlutter circuitAtrial appendageRight atriumVena cavaElectroanatomic mappingElectroanatomic mapsOblique courseCycle lengthPatientsSimilar activationActivation mappingAnteriorFlutterActivationIntervalCavaAtrium
2008
Endothelial dysfunction in heart failure identifies responders to cardiac resynchronization therapy
Akar JG, Al-Chekakie MO, Fugate T, Moran L, Froloshki B, Varma N, Santucci P, Wilber DJ, Matsumura ME. Endothelial dysfunction in heart failure identifies responders to cardiac resynchronization therapy. Heart Rhythm 2008, 5: 1229-1235. PMID: 18774094, DOI: 10.1016/j.hrthm.2008.05.027.Peer-Reviewed Original ResearchConceptsCardiac resynchronization therapyFlow-mediated dilationBaseline flow-mediated dilationBaseline endothelial dysfunctionAdditive prognostic valueEndothelial dysfunctionCRT respondersWalk distanceResynchronization therapyPrognostic valueBrachial artery flow-mediated dilationArtery flow-mediated dilationBaseline functional capacityEndothelial function assessmentHeart failure mortalityHeart failure outcomesLikelihood of responseLogistic regression analysisQuality of lifeCurrent selection criteriaEndothelial functionHeart failureQRS durationCurrent guidelinesFunction assessment
2003
Intracellular Chloride Accumulation and Subcellular Elemental Distribution During Atrial Fibrillation
Akar JG, Everett TH, Ho R, Craft J, Haines DE, Somlyo AP, Somlyo AV. Intracellular Chloride Accumulation and Subcellular Elemental Distribution During Atrial Fibrillation. Circulation 2003, 107: 1810-1815. PMID: 12665494, DOI: 10.1161/01.cir.0000058462.23347.93.Peer-Reviewed Original ResearchConceptsEffective refractory periodLeft atrial appendageAtrial fibrillationMitochondrial Ca overloadWhole-cell ClWhole-cell NaIntracellular chloride accumulationIntracellular Cl- accumulationSinus rhythmAtrial appendageCa overloadElectrical remodelingAF pathogenesisRapid pacingRefractory periodTransient increaseTransverse cryosectionsMembrane depolarizationFibrillationNovel findingsCytosolic CaCytoplasmic CaConcomitant increaseIon channelsMinutes
2002
Use of global atrial fibrillation organization to optimize the success of burst pace termination
Everett TH, Akar JG, Kok LC, Moorman JR, Haines DE. Use of global atrial fibrillation organization to optimize the success of burst pace termination. Journal Of The American College Of Cardiology 2002, 40: 1831-1840. PMID: 12446068, DOI: 10.1016/s0735-1097(02)02476-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAtrial FibrillationCardiac Pacing, ArtificialDisease Models, AnimalDogsElectrophysiologic Techniques, CardiacHeart AtriaModels, CardiovascularTreatment OutcomeConceptsAtrial fibrillationRight atriumPace terminationBiatrial pacingAtrial conduction blockSuccess rateBipolar atrial electrogramOverall success rateOrganization indexAtrial pacingDecapolar catheterConduction blockAtrial electrogramsBurst terminationElectrogram recordingsPacingHigh efficacyAtrial fibrillation organizationFibrillation
2001
Assessment of Global Atrial Fibrillation Organization to Optimize Timing of Atrial Defibrillation
Everett T, Moorman J, Kok L, Akar J, Haines D. Assessment of Global Atrial Fibrillation Organization to Optimize Timing of Atrial Defibrillation. Circulation 2001, 103: 2857-2861. PMID: 11401945, DOI: 10.1161/01.cir.103.23.2857.Peer-Reviewed Original Research