2010
Pericardial Fat Is Independently Associated With Human Atrial Fibrillation
Chekakie M, Welles CC, Metoyer R, Ibrahim A, Shapira AR, Cytron J, Santucci P, Wilber DJ, Akar JG. Pericardial Fat Is Independently Associated With Human Atrial Fibrillation. Journal Of The American College Of Cardiology 2010, 56: 784-788. PMID: 20797492, DOI: 10.1016/j.jacc.2010.03.071.Peer-Reviewed Original ResearchConceptsPericardial fat volumeParoxysmal atrial fibrillationPersistent atrial fibrillationAtrial fibrillationPericardial fatFat volumeAtrial enlargementSinus rhythmPathogenesis of AFSinus rhythm groupTraditional risk factorsVentricular ejection fractionValvular heart diseaseBody mass indexVisceral adipose tissuePersistent AF patientsHuman atrial fibrillationAF independentAF patientsDiabetes mellitusEjection fractionMass indexHeart diseaseRisk factorsInflammatory properties
2008
Acute Onset Human Atrial Fibrillation Is Associated With Local Cardiac Platelet Activation and Endothelial Dysfunction
Akar JG, Jeske W, Wilber DJ. Acute Onset Human Atrial Fibrillation Is Associated With Local Cardiac Platelet Activation and Endothelial Dysfunction. Journal Of The American College Of Cardiology 2008, 51: 1790-1793. PMID: 18452786, DOI: 10.1016/j.jacc.2007.11.083.Peer-Reviewed Original ResearchConceptsAcute onset atrial fibrillationSystemic platelet activationRisk factorsPlatelet activationHypercoagulable stateAtrial fibrillationAF groupThrombin generationBlood samplesControl groupUnderwent radiofrequency catheter ablationPlatelet P-selectin expressionOnset atrial fibrillationBaseline blood samplesRadiofrequency catheter ablationMinutes of onsetBeats/minP-selectin expressionBurst atrial pacingHuman atrial fibrillationNitric oxide productionEnzyme-linked immunosorbentLocal thrombin generationInflammatory markersProthrombotic state