Psychiatric Comorbidity in Mexican Adolescents with a Diagnosis of Eating Disorders Its Relationship with the Body Mass Index
Ruiz-Ramos D, Martínez-Magaña JJ, García AR, Juarez-Rojop IE, Gonzalez-Castro TB, Tovilla-Zarate CA, Sarmiento E, López-Narvaez ML, Nicolini H, Genis-Mendoza AD. Psychiatric Comorbidity in Mexican Adolescents with a Diagnosis of Eating Disorders Its Relationship with the Body Mass Index. International Journal Of Environmental Research And Public Health 2021, 18: 3900. PMID: 33917708, PMCID: PMC8068102, DOI: 10.3390/ijerph18083900.Peer-Reviewed Original ResearchConceptsBody mass indexComorbid psychiatric disordersMass indexPsychiatric comorbidityPsychiatric disordersED diagnosisHigher body mass indexMini International Neuropsychiatric InterviewMexican adolescentsPresence of comorbiditiesInternational Neuropsychiatric InterviewMajor depressive disorderBinge-eating disorderChildren/adolescentsPrevalent comorbiditiesNeuropsychiatric InterviewDepressive disorderComorbiditiesGeneral populationDisorder prevalenceSevere metabolic disruptionsIntegrative treatmentMetabolic disruptionSuicide riskPrevalenceCandidate pharmacological treatments for substance use disorder and suicide identified by gene co‐expression network‐based drug repositioning
Cabrera‐Mendoza B, Martínez‐Magaña J, Monroy‐Jaramillo N, Genis‐Mendoza A, Fresno C, Fries GR, Walss‐Bass C, Armenta M, García‐Dolores F, Díaz‐Otañez C, Flores G, Vázquez‐Roque R, Nicolini H. Candidate pharmacological treatments for substance use disorder and suicide identified by gene co‐expression network‐based drug repositioning. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2021, 186: 193-206. PMID: 33403748, DOI: 10.1002/ajmg.b.32830.Peer-Reviewed Original ResearchConceptsSubstance use disordersUse disordersBrain gene co-expression networksHub genesPotential pharmacological targetPost-mortem samplesPharmacological treatmentHigh riskCandidate treatmentPharmacological targetsSuicidal behaviorMAOA inhibitorsPrefrontal cortexNonsuicidesDGIdb databaseGene expression profilesPatientsCo-expression networkSuicideDisordersDrugsTreatmentDrug repositioningExpression profilesIndividuals