2001
CdtA, CdtB, and CdtC Form a Tripartite Complex That Is Required for Cytolethal Distending Toxin Activity
Lara-Tejero M, Galán J. CdtA, CdtB, and CdtC Form a Tripartite Complex That Is Required for Cytolethal Distending Toxin Activity. Infection And Immunity 2001, 69: 4358-4365. PMID: 11401974, PMCID: PMC98507, DOI: 10.1128/iai.69.7.4358-4365.2001.Peer-Reviewed Original ResearchConceptsCytolethal distending toxinTriggers cell cycle arrestActive subunitCell cycle arrestImportant bacterial pathogensTripartite complexCell cycleCDT holotoxinDistending toxinCycle arrestCDT activityCellular toxicityCdtCSubunitsBacterial pathogensRelated toxinsCdtBToxin activityB chainB subunitCdtC.Toxic activityTripartite toxinCampylobacter jejuniTarget cells
2000
A Bacterial Toxin That Controls Cell Cycle Progression as a Deoxyribonuclease I-Like Protein
Lara-Tejero M, Galán J. A Bacterial Toxin That Controls Cell Cycle Progression as a Deoxyribonuclease I-Like Protein. Science 2000, 290: 354-357. PMID: 11030657, DOI: 10.1126/science.290.5490.354.Peer-Reviewed Original ResearchConceptsCell cycle arrestCytolethal distending toxinChromatin disruptionCycle arrestCell cycle progressionLike proteinCdtB mutantChromatin fragmentationTransient expressionMutant formsCycle progressionCell deathCDT holotoxinDistending toxinCultured cellsBacterial toxinsDeoxyribonuclease IBacterial pathogensSuch pathogensCdtBSubunitsCampylobacter jejuniToxinMorphological changesPathogensDevelopmental Control of Endocytosis in Dendritic Cells by Cdc42
Garrett W, Chen L, Kroschewski R, Ebersold M, Turley S, Trombetta S, Galán J, Mellman I. Developmental Control of Endocytosis in Dendritic Cells by Cdc42. Cell 2000, 102: 325-334. PMID: 10975523, DOI: 10.1016/s0092-8674(00)00038-6.Peer-Reviewed Original Research
1996
CROSS-TALK BETWEEN BACTERIAL PATHOGENS AND THEIR HOST CELLS
Galán J, Bliska J. CROSS-TALK BETWEEN BACTERIAL PATHOGENS AND THEIR HOST CELLS. Annual Review Of Cell And Developmental Biology 1996, 12: 221-255. PMID: 8970727, DOI: 10.1146/annurev.cellbio.12.1.221.Peer-Reviewed Original ResearchConceptsHost cellsHost cell signal transduction pathwaysProtein secretion systemHost cellular functionsSpecialized protein secretion systemSignal transduction pathwaysBacterial pathogensHost cell interactionsSecretion systemTransduction pathwaysBacterial proteinsCell physiologyBiochemical interactionsDiverse groupPathogensNovel therapeutic approachesCellsProteinTranslocationBetter understandingInteractionPathwayPhysiologyTherapeutic approachesBasic aspects