2000
Human TNF Can Induce Nonspecific Inflammatory and Human Immune-Mediated Microvascular Injury of Pig Skin Xenografts in Immunodeficient Mouse Hosts
Kirkiles-Smith N, Tereb D, Kim R, McNiff J, Schechner J, Lorber M, Pober J, Tellides G. Human TNF Can Induce Nonspecific Inflammatory and Human Immune-Mediated Microvascular Injury of Pig Skin Xenografts in Immunodeficient Mouse Hosts. The Journal Of Immunology 2000, 164: 6601-6609. PMID: 10843720, DOI: 10.4049/jimmunol.164.12.6601.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAdultAnimalsCell Adhesion MoleculesDose-Response Relationship, ImmunologicDrug SynergismEndothelium, VascularGraft RejectionHistocompatibility AntigensHumansInterferon-gammaMiceMice, Inbred C57BLMice, SCIDMicrocirculationSevere Combined ImmunodeficiencySkin TransplantationSwineT-LymphocytesTransplantation, HeterologousTumor Necrosis Factor-alphaUp-RegulationConceptsHuman T-cell infiltrationPig skin xenograftsT cell infiltrationSkin xenograftsCell infiltrationHuman TNFIFN-gammaE-selectinT cell-mediated rejectionEndothelial cellsAdhesion moleculesCytokine-mediated injuryNonspecific inflammatory damagePig skin graftsCell-mediated rejectionAppropriate therapeutic targetsImmunodeficient mouse modelPorcine E-selectinEndothelial adhesion moleculesPorcine IFN-gammaClass II moleculesHuman skin allograftsMHC class IPorcine endothelial cellsImmunodeficient mouse hosts
1998
Dermal Microvascular Injury in the Human Peripheral Blood Lymphocyte Reconstituted-Severe Combined Immunodeficient (HuPBL-SCID) Mouse/Skin Allograft Model Is T Cell Mediated and Inhibited by a Combination of Cyclosporine and Rapamycin
Murray A, Schechner J, Epperson D, Sultan P, McNiff J, Hughes C, Lorber M, Askenase P, Pober J. Dermal Microvascular Injury in the Human Peripheral Blood Lymphocyte Reconstituted-Severe Combined Immunodeficient (HuPBL-SCID) Mouse/Skin Allograft Model Is T Cell Mediated and Inhibited by a Combination of Cyclosporine and Rapamycin. American Journal Of Pathology 1998, 153: 627-638. PMID: 9708821, PMCID: PMC1852982, DOI: 10.1016/s0002-9440(10)65604-0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsB-LymphocytesCD8-Positive T-LymphocytesCyclosporineDrug Therapy, CombinationEndothelium, VascularEnzyme-Linked Immunosorbent AssayFlow CytometryGenes, MHC Class IIGraft RejectionHumansImmunosuppressive AgentsKeratinocytesMiceMice, SCIDMicrocirculationPolyenesSirolimusSkinSkin TransplantationT-LymphocytesTransplantation, HomologousVascular Cell Adhesion Molecule-1ConceptsPeripheral blood mononuclear cellsHuman peripheral blood mononuclear cellsSkin allograft modelMicrovascular injuryT cellsCell infiltrateAllograft modelWhole peripheral blood mononuclear cellsT cell-dependent mechanismT cell-mediated rejectionHuman natural killer cellsSCID/beige miceEndothelial cell sloughingT Cell-MediatedCell-mediated rejectionCombination of cyclosporineT-cell infiltratesCell-dependent mechanismMononuclear cell infiltrateNatural killer cellsMononuclear cell infiltrationBlood mononuclear cellsSkin graft modelHuman immune responseImmunoglobulin G antibodies
1997
Mechanism of sustained E-selectin expression in cultured human dermal microvascular endothelial cells.
Kluger MS, Johnson DR, Pober JS. Mechanism of sustained E-selectin expression in cultured human dermal microvascular endothelial cells. The Journal Of Immunology 1997, 158: 887-96. PMID: 8993008, DOI: 10.4049/jimmunol.158.2.887.Peer-Reviewed Original Research
1994
Human T-cell-mediated destruction of allogeneic dermal microvessels in a severe combined immunodeficient mouse.
Murray AG, Petzelbauer P, Hughes CC, Costa J, Askenase P, Pober JS. Human T-cell-mediated destruction of allogeneic dermal microvessels in a severe combined immunodeficient mouse. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 9146-9150. PMID: 8090783, PMCID: PMC44764, DOI: 10.1073/pnas.91.19.9146.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsGraft RejectionHumansMiceMice, SCIDMicrocirculationSkinSkin TransplantationT-LymphocytesTransplantation, HeterologousConceptsSignificant T-cell infiltrationT-cell-mediated injuryT cell-mediated destructionVascular cell adhesion molecule-1Human microvesselsSevere combined immunodeficient (SCID) miceMajor histocompatibility complex (MHC) class II moleculesCell adhesion molecule-1Human allograft rejectionT-cell infiltratesT cell infiltrationCombined Immunodeficient MiceImmunodeficient mouse modelAdhesion molecule-1Human skin graftsClass II moleculesPotential therapeutic reagentSmall animal modelsHuman vascular endotheliumAllograft rejectionSkin rejectionMouse microvesselsSkin graftsT cellsImmunodeficient miceInducibility and Expression of Microvascular Endothelial Adhesion Molecules in Lesional, Perilesional, and Uninvolved Skin of Psoriatic Patients
Petzelbauer P, Pober J, Keh A, Braverman I. Inducibility and Expression of Microvascular Endothelial Adhesion Molecules in Lesional, Perilesional, and Uninvolved Skin of Psoriatic Patients. Journal Of Investigative Dermatology 1994, 103: 300-305. PMID: 7521374, DOI: 10.1111/1523-1747.ep12394720.Peer-Reviewed Original ResearchConceptsVascular cell adhesion molecule-1Endothelial leukocyte adhesion molecule-1Lesional skinAdhesion molecule-1Psoriatic patientsEndothelial cellsUninvolved skinPerilesional skinMolecule-1Dermal microvasculatureCapillary loopsCell adhesion molecule-1Perivascular inflammatory infiltratesLeukocyte adhesion molecule-1VCAM-1 expressionTumor necrosis factorEndothelial adhesion moleculesMicrovascular endothelial cellsEndothelial cell expressionVenular endothelial cellsInflammatory infiltrateEpidermal involvementPsoriatic plaquesSuperficial plexusNecrosis factor
1989
Tumor necrosis factor and interferon-gamma induce distinct patterns of endothelial activation and associated leukocyte accumulation in skin of Papio anubis.
Munro JM, Pober JS, Cotran RS. Tumor necrosis factor and interferon-gamma induce distinct patterns of endothelial activation and associated leukocyte accumulation in skin of Papio anubis. American Journal Of Pathology 1989, 135: 121-33. PMID: 2505619, PMCID: PMC1880213.Peer-Reviewed Original ResearchConceptsLeukocyte accumulationNecrosis factorIFN-gammaEndothelial cell antigen expressionAdhesion moleculesAnti-intercellular adhesion moleculeEndothelial cell hypertrophyPolymorphonuclear leukocyte accumulationTumor necrosis factorCytokine-activated endotheliumLeukocyte adhesion moleculesCell antigen expressionImmune inflammationEndothelial activationLeukocyte infiltrationHypersensitivity reactionsMononuclear cellsHLA-DPEnvelope antigenAntigen expressionVascular permeabilitySubsequent extravasationRecombinant human interferonCell hypertrophyEndothelial morphology