2020
Mural Cell-Specific Deletion of Cerebral Cavernous Malformation 3 in the Brain Induces Cerebral Cavernous Malformations
Wang K, Zhang H, He Y, Jiang Q, Tanaka Y, Park IH, Pober JS, Min W, Zhou HJ. Mural Cell-Specific Deletion of Cerebral Cavernous Malformation 3 in the Brain Induces Cerebral Cavernous Malformations. Arteriosclerosis Thrombosis And Vascular Biology 2020, 40: 2171-2186. PMID: 32640906, DOI: 10.1161/atvbaha.120.314586.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosis Regulatory ProteinsBrainCell CommunicationCell MovementCells, CulturedCoculture TechniquesEndothelial CellsFemaleFocal AdhesionsGene DeletionGenetic Predisposition to DiseaseHemangioma, Cavernous, Central Nervous SystemHumansMaleMembrane ProteinsMice, KnockoutMicrovesselsMyocytes, Smooth MusclePaxillinPericytesPhenotypeProtein StabilityProto-Oncogene ProteinsSignal TransductionConceptsCerebral cavernous malformationsBrain mural cellsCCM lesionsMural cellsCavernous malformationsSevere brain hemorrhageCCM pathogenesisSmooth muscle cellsWeeks of ageCell-specific deletionMural cell coverageBrain pericytesBrain hemorrhageNeonatal stageBrain vasculatureLesionsEntire brainMuscle cellsCerebral cavernous malformation 3Endothelial cellsMicePericytesSpecific deletionAdhesion formationPathogenesis
1998
Human endothelial cells induce and regulate cytolytic T cell differentiation.
Biedermann B, Pober J. Human endothelial cells induce and regulate cytolytic T cell differentiation. The Journal Of Immunology 1998, 161: 4679-87. PMID: 9794397, DOI: 10.4049/jimmunol.161.9.4679.Peer-Reviewed Original ResearchConceptsB lymphoblastoid cellsEndothelial cellsHuman endothelial cellsSame donorT cellsProliferation of CD8IFN-gamma secretionCultured human endothelial cellsT cell differentiationT cell growthAllogeneic CD8CTL responsesPerforin expressionCTL differentiationPresence of ECT lymphocytesAllospecific CTLCD8CTLEfficient stimulatorsLymphoblastoid cellsCell numberReproducible frequencyCell growthInput cell number
1996
Endothelial cells augment the expression of CD40 ligand on newly activated human CD4+ T cells through a CD2/LFA‐3 signaling pathway
Karmann K, Hughes C, Fanslow W, Pober J. Endothelial cells augment the expression of CD40 ligand on newly activated human CD4+ T cells through a CD2/LFA‐3 signaling pathway. European Journal Of Immunology 1996, 26: 610-617. PMID: 8605928, DOI: 10.1002/eji.1830260316.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntigens, Differentiation, T-LymphocyteB-LymphocytesCD2 AntigensCD40 LigandCD4-Positive T-LymphocytesCD58 AntigensCell AdhesionCell CommunicationCells, CulturedEndothelium, VascularHumansInterleukin-2LigandsLymphocyte ActivationMembrane GlycoproteinsPhytohemagglutininsSignal TransductionUp-RegulationConceptsCD40 ligand expressionExogenous IL-2T cellsIL-2Ligand expressionCD2/LFACD40 ligandHuman peripheral blood CD4Peripheral blood adherent cellsHelper T cell subsetsPeripheral blood T cellsPeripheral blood CD4T cell subsetsCo-stimulatory moleculesBlood T cellsHelper T cellsIL-2 receptorCo-stimulatory signalsIL-2 secretionInterleukin-2 secretionBlood CD4Endothelial effectsCell subsetsHuman CD4B cells
1984
Interactions of T Lymphocytes with Human Vascular Endothelial Cells: Role of Endothelial Cells Surface Antigens
Pober JS, Gimbrone MA, Collins T, Cotran RS, Ault KA, Fiers W, Krensky AM, Clayberger C, Reiss C, Burakoff SJ. Interactions of T Lymphocytes with Human Vascular Endothelial Cells: Role of Endothelial Cells Surface Antigens. Immunobiology 1984, 168: 483-494. PMID: 6397428, DOI: 10.1016/s0171-2985(84)80132-1.Peer-Reviewed Original ResearchConceptsClass II antigensVascular endothelial cellsMajor histocompatibility complexII antigensT cellsClass II moleculesHuman vascular endothelial cellsActivated T cellsEndothelial cellsStromal cellsImmune interferonT lymphocytesAntigen-specific T cellsPeripheral blood T lymphocytesClass IHelper T cell clonesImmune accessory functionNon-MHC antigensWithdrawal of interferonClass II major histocompatibility complexCultured human vascular endothelial cellsT cell responsesVascular smooth muscle cellsBlood T lymphocytesHuman class II antigensHuman cytolytic T lymphocyte interactions with vascular endothelium and fibroblasts: role of effector and target cell molecules.
Collins T, Krensky AM, Clayberger C, Fiers W, Gimbrone MA, Burakoff SJ, Pober JS. Human cytolytic T lymphocyte interactions with vascular endothelium and fibroblasts: role of effector and target cell molecules. The Journal Of Immunology 1984, 133: 1878-84. PMID: 6432903, DOI: 10.4049/jimmunol.133.4.1878.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, MonoclonalAntigens, SurfaceBinding Sites, AntibodyCell CommunicationCytotoxicity, ImmunologicEndotheliumFibroblastsHistocompatibility Antigens Class IIHLA-DR AntigensHumansIndiumInterferon-gammaLymphocyte Function-Associated Antigen-1RadioisotopesT-LymphocytesT-Lymphocytes, CytotoxicUmbilical VeinsConceptsCytolytic T lymphocytesVascular endotheliumCultured human vascular endotheliumLFA-1LFA-2Human cytolytic T lymphocytesHuman CTL linesT lymphocyte interactionsCell typesSame CTL clonesImportant target cellsTarget cell structuresHuman vascular endotheliumLymphoid targetsHost diseaseAllograft rejectionImmune injuryHLA-DRCell surface moleculesCTL linesCTL clonesT lymphocytesLymphocyte interactionsTarget cell typeLFA-3