2023
MicroRNA-1 protects the endothelium in acute lung injury
Korde A, Haslip M, Pednekar P, Khan A, Chioccioli M, Mehta S, Lopez-Giraldez F, Bermejo S, Rojas M, Dela Cruz C, Matthay M, Pober J, Pierce R, Takyar S. MicroRNA-1 protects the endothelium in acute lung injury. JCI Insight 2023, 8: e164816. PMID: 37737266, PMCID: PMC10561733, DOI: 10.1172/jci.insight.164816.Peer-Reviewed Original ResearchMeSH KeywordsAcute Lung InjuryAnimalsEndotheliumHumansMiceMicroRNAsRespiratory Distress SyndromeVascular Endothelial Growth Factor AConceptsAcute respiratory distress syndromeAcute lung injuryVascular endothelial growth factorAngiopoietin-2Lung injuryAcute injuryMiR-1MicroRNA-1Endothelial cell-specific overexpressionSevere endothelial dysfunctionRespiratory distress syndromeSurvival of miceIntrinsic protective effectContext of injuryCell-specific overexpressionEndothelial growth factorFamily member 3Pneumonia cohortMiR-1 targetsEndothelial dysfunctionDistress syndromeBarrier dysfunctionCapillary leakProtective effectSevere form
2013
Pericytes modulate endothelial sprouting
Chang WG, Andrejecsk JW, Kluger MS, Saltzman WM, Pober JS. Pericytes modulate endothelial sprouting. Cardiovascular Research 2013, 100: 492-500. PMID: 24042014, PMCID: PMC3826704, DOI: 10.1093/cvr/cvt215.Peer-Reviewed Original ResearchMeSH KeywordsBecaplerminCoculture TechniquesCulture Media, ConditionedHepatocyte Growth FactorHuman Umbilical Vein Endothelial CellsHumansMicrovesselsNeovascularization, PhysiologicParacrine CommunicationPericytesProto-Oncogene Proteins c-bcl-2Proto-Oncogene Proteins c-sisSignal TransductionSpheroids, CellularTime FactorsTransfectionVascular Endothelial Growth Factor A
2001
Suppression of Vascular Endothelial Growth Factor-Mediated Endothelial Cell Protection by Survivin Targeting
Mesri M, Morales-Ruiz M, Ackermann E, Bennett C, Pober J, Sessa W, Altieri D. Suppression of Vascular Endothelial Growth Factor-Mediated Endothelial Cell Protection by Survivin Targeting. American Journal Of Pathology 2001, 158: 1757-1765. PMID: 11337373, PMCID: PMC1891951, DOI: 10.1016/s0002-9440(10)64131-4.Peer-Reviewed Original ResearchApoptosisCell MovementCells, CulturedDNADNA, AntisenseDose-Response Relationship, DrugEndothelial Growth FactorsEndothelium, VascularGene Expression RegulationHumansInhibitor of Apoptosis ProteinsLymphokinesMicrotubule-Associated ProteinsNeoplasm ProteinsProteinsRNA, MessengerSurvivinVascular Endothelial Growth Factor AVascular Endothelial Growth Factors
2000
Control of Apoptosis during Angiogenesis by Survivin Expression in Endothelial Cells
O'Connor D, Schechner J, Adida C, Mesri M, Rothermel A, Li F, Nath A, Pober J, Altieri D. Control of Apoptosis during Angiogenesis by Survivin Expression in Endothelial Cells. American Journal Of Pathology 2000, 156: 393-398. PMID: 10666367, PMCID: PMC1850029, DOI: 10.1016/s0002-9440(10)64742-6.Peer-Reviewed Original ResearchMeSH KeywordsApoptosisCell DivisionCell SurvivalCells, CulturedEndothelial Growth FactorsEndothelium, VascularFibroblast Growth Factor 2HumansInhibitor of Apoptosis ProteinsLymphokinesMicrotubule-Associated ProteinsMitogensNeoplasm ProteinsNeovascularization, PhysiologicProteinsSurvivinVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsConceptsTumor necrosis factor alpha/cycloheximideControl of apoptosisEndothelial cellsSurvivin expressionQuiescent endothelial cellsEndothelial cell survivalGrowth factorApoptosis inhibitor survivinTwo-dimensional cultureCaspase-3 activityRecombinant expressionFibroblast growth factorBasic fibroblast growth factorCell survivalStrong inductionProtein survivinPathological angiogenesisProtective genesRNA expressionVascular tubesSurvivinExpressionVascular endothelial growth factorApoptosisCells
1998
Endothelial cells in physiology and in the pathophysiology of vascular disorders.
Cines DB, Pollak ES, Buck CA, Loscalzo J, Zimmerman GA, McEver RP, Pober JS, Wick TM, Konkle BA, Schwartz BS, Barnathan ES, McCrae KR, Hug BA, Schmidt AM, Stern DM. Endothelial cells in physiology and in the pathophysiology of vascular disorders. Blood 1998, 91: 3527-61. PMID: 9572988.Peer-Reviewed Original ResearchAnimalsArteriosclerosisBlood CellsBlood CoagulationCell AdhesionCell Adhesion MoleculesCell DifferentiationCells, CulturedEndothelial Growth FactorsEndothelinsEndothelium, VascularEpoprostenolExtracellular MatrixFemaleFibrinolysisFibroblast Growth Factor 2HemodynamicsHumansInflammationLymphokinesMaleMiceNeovascularization, PhysiologicNitric OxidePlatelet Activating FactorPre-EclampsiaPregnancyThrombosisUmbilical VeinsVascular DiseasesVascular Endothelial Growth Factor AVascular Endothelial Growth Factors