Selective labelling of the hydrophobic segments of intrinsic membrane proteins with a lipophilic photogenerated carbene
GOLDMAN D, POBER J, WHITE J, BAYLEY H. Selective labelling of the hydrophobic segments of intrinsic membrane proteins with a lipophilic photogenerated carbene. Nature 1979, 280: 841-843. PMID: 471056, DOI: 10.1038/280841a0.Peer-Reviewed Original ResearchMeSH KeywordsAdamantaneBridged-Ring CompoundsGlycophorinsHemagglutinins, ViralHLA AntigensHumansMembrane LipidsMembrane ProteinsSolubilityViral ProteinsConceptsIntrinsic membrane proteinsMembrane proteinsLipid bilayersCarbon-hydrogen bondsMembrane-associated regionsHydrophobic amino acidsProtein segmentsAryl azidesCarbeneHydrophobic peptidesReactive speciesAryl nitrenesBiological membranesNitreneAmino acidsHydrophobic segmentsHydrocarbon regionProteinGlycophorin ASelective labelingBilayersReagentsLipophilicReactivityAttractive candidate