1993
HUMAN CD4+ T CELLS PROLIFERATE TO HLA-DR+ ALLOGENEIC VASCULAR ENDOTHELIUM
SAVAGE C, HUGHES C, MCINTYRE B, PICARD J, POBER J. HUMAN CD4+ T CELLS PROLIFERATE TO HLA-DR+ ALLOGENEIC VASCULAR ENDOTHELIUM. Transplantation 1993, 56: 128-134. PMID: 7687392, DOI: 10.1097/00007890-199307000-00024.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, MonoclonalAntigens, CDAntigens, Differentiation, T-LymphocyteCD2 AntigensCD4 AntigensCD58 AntigensCells, CulturedEndothelium, VascularFlow CytometryHistocompatibility Antigens Class IHLA-DR AntigensHumansInterferon-gammaLymphocyte ActivationMembrane GlycoproteinsPolymerase Chain ReactionReceptors, ImmunologicRecombinant ProteinsT-Lymphocyte SubsetsTransplantation, HomologousUmbilical VeinsConceptsHLA-DR expressing cellsT cellsHLA-DRPolymerase chain reactionEC culturesAllogeneic class II MHC moleculesMHC moleculesLFA-1 beta chainLFA-1Peripheral blood CD4VLA-4 alphaMHC class II moleculesT cell responsesClass II MHC moleculesT cell surface moleculesT cell proliferationClass I MHC moleculesExpressing cellsClass II moleculesBeta chainII MHC moleculesDe novo expressionI MHC moleculesAllogeneic proliferationBlood CD4
1991
Human coronary transplantation-associated arteriosclerosis. Evidence for a chronic immune reaction to activated graft endothelial cells.
Salomon RN, Hughes CC, Schoen FJ, Payne DD, Pober JS, Libby P. Human coronary transplantation-associated arteriosclerosis. Evidence for a chronic immune reaction to activated graft endothelial cells. American Journal Of Pathology 1991, 138: 791-8. PMID: 2012171, PMCID: PMC1886118.Peer-Reviewed Original ResearchConceptsHuman cardiac allograftsCoronary arteryT lymphocytesCardiac allograftsEndothelial cellsT cellsChronic immune reactionsDonor coronary arteriesRecipient T lymphocytesRegional immune responsesClass II major histocompatibility complexGraft endothelial cellsSmooth muscle cell proliferationAllogeneic T cellsAbility of HLAHuman arteriesLong-term survivalMuscle cell proliferationCoronary arterial endotheliumMajor histocompatibility complexNormal human arteriesTypical atherosclerosisOcclusive diseaseHLA-DRTransplanted hearts
1990
Lymphocyte-mediated activation of cultured endothelial cells (EC). CD4+ T cells inhibit EC class II MHC expression despite secreting IFN-gamma and increasing EC class I MHC and intercellular adhesion molecule-1 expression.
Doukas J, Pober JS. Lymphocyte-mediated activation of cultured endothelial cells (EC). CD4+ T cells inhibit EC class II MHC expression despite secreting IFN-gamma and increasing EC class I MHC and intercellular adhesion molecule-1 expression. The Journal Of Immunology 1990, 145: 1088-98. PMID: 1974272, DOI: 10.4049/jimmunol.145.4.1088.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, Differentiation, T-LymphocyteCD4 AntigensCD4-Positive T-LymphocytesCD8 AntigensCell Adhesion MoleculesCells, CulturedEndothelium, VascularHistocompatibility Antigens Class IHistocompatibility Antigens Class IIHumansImmune SeraInterferon-gammaPhytohemagglutininsT-Lymphocytes, RegulatoryConceptsClass II MHC expressionIntercellular adhesion molecule-1 expressionClass I MHCAdhesion molecule-1 expressionClass II AgClass II expressionMolecule-1 expressionT cellsMHC expressionIFN-gammaI MHCEndothelial cellsICAM-1Class II MHC inductionClass IClass II MHC AgCoculture of CD4Failure of CD4Immunoreactive IFN-gammaICAM-1 expressionClass II MHCCultured endothelial cellsUnfractionated PBLTime of inductionMHC inductionEndothelial cells augment T cell interleukin 2 production by a contact-dependent mechanism involving CD2/LFA-3 interaction.
Hughes CC, Savage CO, Pober JS. Endothelial cells augment T cell interleukin 2 production by a contact-dependent mechanism involving CD2/LFA-3 interaction. Journal Of Experimental Medicine 1990, 171: 1453-1467. PMID: 1692079, PMCID: PMC2187887, DOI: 10.1084/jem.171.5.1453.Peer-Reviewed Original Research