1997
Activation of monocyte/macrophage functions related to acute atheroma complication by ligation of CD40: induction of collagenase, stromelysin, and tissue factor.
Mach F, Schönbeck U, Bonnefoy J, Pober J, Libby P. Activation of monocyte/macrophage functions related to acute atheroma complication by ligation of CD40: induction of collagenase, stromelysin, and tissue factor. Circulation 1997, 96: 396-9. PMID: 9244201, DOI: 10.1161/01.cir.96.2.396.Peer-Reviewed Original ResearchConceptsLigation of CD40Tissue factorMacrophage functionMonocyte/macrophage functionAcute coronary eventsAcute coronary syndromeAnti-CD40L antibodyHuman monocytes/macrophagesCytokine interleukin-1Mononuclear phagocyte functionMonocytes/macrophagesInduction of collagenaseActivated T cellsCoronary eventsCoronary syndromeMatrix-degrading proteinasesClinical manifestationsPlaque disruptionTumor necrosisT cell membranePlaque ruptureT cellsInterleukin-1Phagocyte functionReceptor CD40
1986
Induction and detection of a human endothelial activation antigen in vivo.
Cotran RS, Gimbrone MA, Bevilacqua MP, Mendrick DL, Pober JS. Induction and detection of a human endothelial activation antigen in vivo. Journal Of Experimental Medicine 1986, 164: 661-666. PMID: 3723080, PMCID: PMC2188244, DOI: 10.1084/jem.164.2.661.Peer-Reviewed Original ResearchConceptsEndothelial activation antigenActivation antigensSequential skin biopsiesStrong positive stainingHuman umbilical vein endothelial cell culturesEndothelial cell functionLymph nodesHypersensitivity reactionsSkin biopsiesInflammatory reactionImmunoperoxidase techniqueVascular endotheliumPositive stainingEndothelial cell culturesNormal endotheliumMurine mAbsUseful markerH4/18EndotheliumAntigenCell functionSkinPathological tissuesHuman skinTissue
1985
Interleukin-1 activation of vascular endothelium. Effects on procoagulant activity and leukocyte adhesion.
Bevilacqua MP, Pober JS, Wheeler ME, Cotran RS, Gimbrone MA. Interleukin-1 activation of vascular endothelium. Effects on procoagulant activity and leukocyte adhesion. American Journal Of Pathology 1985, 121: 394-403. PMID: 3878084, PMCID: PMC1887931.Peer-Reviewed Original ResearchConceptsInterleukin-1Procoagulant activityHuman endothelial cellsEndothelial cellsVascular endotheliumTissue factor-like procoagulant activityLeukocyte adhesionPeripheral blood polymorphonuclear leukocytesHuman peripheral blood polymorphonuclear leukocytesCultured human vascular endothelial cellsBlood polymorphonuclear leukocytesIL-1 actionIL-1 effectsRecombinant IL-1Sites of inflammationHuman vascular endothelial cellsInterleukin-1 activationVascular endothelial cellsEnhanced leukocyteIntravascular coagulationImmune mediatorsIL-2Saphenous veinEndothelial cell surfaceUmbilical vein
1984
Interleukin 1 (IL-1) induces biosynthesis and cell surface expression of procoagulant activity in human vascular endothelial cells.
Bevilacqua MP, Pober JS, Majeau GR, Cotran RS, Gimbrone MA. Interleukin 1 (IL-1) induces biosynthesis and cell surface expression of procoagulant activity in human vascular endothelial cells. Journal Of Experimental Medicine 1984, 160: 618-623. PMID: 6332168, PMCID: PMC2187463, DOI: 10.1084/jem.160.2.618.Peer-Reviewed Original ResearchMeSH KeywordsBlood CoagulationCell MembraneCells, CulturedEndotheliumHumansInterleukin-1MonocytesThromboplastinUmbilical VeinsConceptsEndothelial cell procoagulant activityCell procoagulant activityProcoagulant activityInterleukin-1Cultured human vascular endotheliumHuman monocyte-derived interleukin 1Coagulation factor-deficient plasmasMonocyte-derived interleukin 1Human vascular endothelial cellsHuman vascular endotheliumVascular endothelial cellsFactor-deficient plasmaIL-1 inductionIntravascular coagulationInflammatory conditionsCell surface expressionIntact cell monolayersVascular endotheliumEndothelial cellsPotent inducerSurface expressionCell monolayersProtein synthesisPathogenesisActivity