1998
Dermal Microvascular Injury in the Human Peripheral Blood Lymphocyte Reconstituted-Severe Combined Immunodeficient (HuPBL-SCID) Mouse/Skin Allograft Model Is T Cell Mediated and Inhibited by a Combination of Cyclosporine and Rapamycin
Murray A, Schechner J, Epperson D, Sultan P, McNiff J, Hughes C, Lorber M, Askenase P, Pober J. Dermal Microvascular Injury in the Human Peripheral Blood Lymphocyte Reconstituted-Severe Combined Immunodeficient (HuPBL-SCID) Mouse/Skin Allograft Model Is T Cell Mediated and Inhibited by a Combination of Cyclosporine and Rapamycin. American Journal Of Pathology 1998, 153: 627-638. PMID: 9708821, PMCID: PMC1852982, DOI: 10.1016/s0002-9440(10)65604-0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsB-LymphocytesCD8-Positive T-LymphocytesCyclosporineDrug Therapy, CombinationEndothelium, VascularEnzyme-Linked Immunosorbent AssayFlow CytometryGenes, MHC Class IIGraft RejectionHumansImmunosuppressive AgentsKeratinocytesMiceMice, SCIDMicrocirculationPolyenesSirolimusSkinSkin TransplantationT-LymphocytesTransplantation, HomologousVascular Cell Adhesion Molecule-1ConceptsPeripheral blood mononuclear cellsHuman peripheral blood mononuclear cellsSkin allograft modelMicrovascular injuryT cellsCell infiltrateAllograft modelWhole peripheral blood mononuclear cellsT cell-dependent mechanismT cell-mediated rejectionHuman natural killer cellsSCID/beige miceEndothelial cell sloughingT Cell-MediatedCell-mediated rejectionCombination of cyclosporineT-cell infiltratesCell-dependent mechanismMononuclear cell infiltrateNatural killer cellsMononuclear cell infiltrationBlood mononuclear cellsSkin graft modelHuman immune responseImmunoglobulin G antibodies
1994
Endothelial cell-induced resistance to cyclosporin A in human peripheral blood T cells requires contact-dependent interactions involving CD2 but not CD28.
Karmann K, Pober JS, Hughes CC. Endothelial cell-induced resistance to cyclosporin A in human peripheral blood T cells requires contact-dependent interactions involving CD2 but not CD28. The Journal Of Immunology 1994, 153: 3929-37. PMID: 7523510, DOI: 10.4049/jimmunol.153.9.3929.Peer-Reviewed Original ResearchConceptsIL-2 secretionT cellsEndothelial cellsPeripheral blood T cellsHuman peripheral blood T cellsGraft endothelial cellsHost T cellsBlood T cellsT cell CD28Cultured human endothelial cellsEndothelial cell ligandsIL-2 synthesisInitiation of cocultureContact-dependent interactionsEffect of ECHuman endothelial cellsT cell CD2Presence of ECInhibitory doseLFA-3Cell ligandsCyclosporin ACD28Cell contactSecretion