IL-4 induction of VCAM-1 on endothelial cells involves activation of a protein tyrosine kinase.
Palmer-Crocker RL, Pober JS. IL-4 induction of VCAM-1 on endothelial cells involves activation of a protein tyrosine kinase. The Journal Of Immunology 1995, 154: 2838-45. PMID: 7533184, DOI: 10.4049/jimmunol.154.6.2838.Peer-Reviewed Original ResearchConceptsVascular cell adhesion molecule-1VCAM-1 expressionEndothelial cellsIL-4 inductionIL-4IL-4R.Cell adhesion molecule-1Pretreatment of ECTreatment of ECIL-4 concentrationsAdhesion molecule-1Cultured human endothelial cellsHerbimycin ATime of treatmentHuman endothelial cellsTyrosine kinaseMolecule-1Western blotProtein tyrosine kinasesTyrosine phosphorylationIL-4-induced tyrosine phosphorylationAnti-phosphotyrosine immunoprecipitatesReplicate wells