2019
Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis
Chen PY, Qin L, Li G, Wang Z, Dahlman JE, Malagon-Lopez J, Gujja S, Cilfone N, Kauffman K, Sun L, Sun H, Zhang X, Aryal B, Canfran-Duque A, Liu R, Kusters P, Sehgal A, Jiao Y, Anderson D, Gulcher J, Fernandez-Hernando C, Lutgens E, Schwartz M, Pober J, Chittenden T, Tellides G, Simons M. Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis. Nature Metabolism 2019, 1: 912-926. PMID: 31572976, PMCID: PMC6767930, DOI: 10.1038/s42255-019-0102-3.Peer-Reviewed Original ResearchConceptsTGF-β signalingVascular inflammationDisease progressionPlaque growthProgressive vascular diseaseVessel wall inflammationChronic inflammatory responseSpecific therapeutic interventionsAtherosclerotic plaque growthHyperlipidemic micePlaque inflammationWall inflammationProinflammatory effectsVascular diseaseInflammatory responseVascular permeabilityAtherosclerotic plaquesAbnormal shear stressTherapeutic interventionsInflammationEndothelial TGFΒ signalingVessel wallAtherosclerosisLipid retention
1992
Recent Insights into the Mechanisms of Vascular Injury
Cotran R, Pober J. Recent Insights into the Mechanisms of Vascular Injury. 1992, 183-189. DOI: 10.1007/978-1-4899-0721-9_11.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsVascular injuryPathogenesis of vasculitisForms of vasculitisSubsequent complement activationCapillary basement membraneBlood vessel wallCytoplasmic antibodiesInflammatory vasculitisWegener's granulomatosisGoodpasture's syndromePathogenetic mechanismsImmune complexesSystemic necrotizingVasculitisComplement activationInjuryEndothelial cellsHeterogeneous groupVessel wallTransplantation reactionsGranulomatosisBasement membraneInflammationSyndromePossible role
1987
Induction and Regulation of Endothelial Gene Expression
Collins T, Pober J. Induction and Regulation of Endothelial Gene Expression. Sitzungsberichte Der Heidelberger Akademie Der Wissenschaften 1987, 155-158. DOI: 10.1007/978-3-642-83118-8_49.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsEndothelial cellsEndothelial gene expressionUnderlying smooth muscle cellsGene expressionSmooth muscle cellsInflammatory mediatorsPathologic lesionsSurface phenotypeVascular intimaPathophysiological processesEndothelial liningEC gene expressionMuscle cellsBlood streamArterial wallBlood cellsVessel wall pathophysiologySecretory productsVessel wallCell surface componentsCellular componentsCellular interactionsCritical determinantCellsExpression