2024
SRF SUMOylation modulates smooth muscle phenotypic switch and vascular remodeling
Xu Y, Zhang H, Chen Y, Pober J, Zhou M, Zhou J, Min W. SRF SUMOylation modulates smooth muscle phenotypic switch and vascular remodeling. Nature Communications 2024, 15: 6919. PMID: 39134547, PMCID: PMC11319592, DOI: 10.1038/s41467-024-51350-5.Peer-Reviewed Original ResearchConceptsVascular smooth muscle cellsSerum response factorCardiovascular diseaseVSMC synthetic phenotypeVascular remodelingNeointimal formationSENP1 deficiencySerum response factor activitySmooth muscle phenotypic switchingPhenotypic switchingPathogenesis of cardiovascular diseaseSmooth muscle cellsPost-translational SUMOylationTreatment of cardiovascular diseasesInhibitor AZD6244Phospho-ELK1Increased nuclear accumulationLysosomal localizationGene transcriptionNuclear accumulationMuscle cellsCoronary arteryCVD patientsVSMC phenotypic switchTherapeutic potential
2007
Activation of Transcription Factor PPARgamma In Vivo Protects Against Alloreactive Vascular Remodeling of Human Artery
Kawikova I, Tai Y, Lorber M, Tellides G, Pober J, Bothwell A. Activation of Transcription Factor PPARgamma In Vivo Protects Against Alloreactive Vascular Remodeling of Human Artery. Clinical Immunology 2007, 123: s175-s176. DOI: 10.1016/j.clim.2007.03.141.Peer-Reviewed Original Research