2022
Nucleic Acid Delivery to the Vascular Endothelium
Reschke M, Piotrowski-Daspit AS, Pober JS, Saltzman WM. Nucleic Acid Delivery to the Vascular Endothelium. Molecular Pharmaceutics 2022, 19: 4466-4486. PMID: 36251765, PMCID: PMC10673694, DOI: 10.1021/acs.molpharmaceut.2c00653.Peer-Reviewed Original Research
2019
Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis
Chen PY, Qin L, Li G, Wang Z, Dahlman JE, Malagon-Lopez J, Gujja S, Cilfone N, Kauffman K, Sun L, Sun H, Zhang X, Aryal B, Canfran-Duque A, Liu R, Kusters P, Sehgal A, Jiao Y, Anderson D, Gulcher J, Fernandez-Hernando C, Lutgens E, Schwartz M, Pober J, Chittenden T, Tellides G, Simons M. Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis. Nature Metabolism 2019, 1: 912-926. PMID: 31572976, PMCID: PMC6767930, DOI: 10.1038/s42255-019-0102-3.Peer-Reviewed Original ResearchConceptsTGF-β signalingVascular inflammationDisease progressionPlaque growthProgressive vascular diseaseVessel wall inflammationChronic inflammatory responseSpecific therapeutic interventionsAtherosclerotic plaque growthHyperlipidemic micePlaque inflammationWall inflammationProinflammatory effectsVascular diseaseInflammatory responseVascular permeabilityAtherosclerotic plaquesAbnormal shear stressTherapeutic interventionsInflammationEndothelial TGFΒ signalingVessel wallAtherosclerosisLipid retention
1985
Interleukin 1 acts on cultured human vascular endothelium to increase the adhesion of polymorphonuclear leukocytes, monocytes, and related leukocyte cell lines.
Bevilacqua MP, Pober JS, Wheeler ME, Cotran RS, Gimbrone MA. Interleukin 1 acts on cultured human vascular endothelium to increase the adhesion of polymorphonuclear leukocytes, monocytes, and related leukocyte cell lines. Journal Of Clinical Investigation 1985, 76: 2003-2011. PMID: 3877078, PMCID: PMC424265, DOI: 10.1172/jci112200.Peer-Reviewed Original ResearchConceptsEndothelial-leukocyte adhesionHuman vascular endotheliumIL-1Leukocyte adhesionVascular endotheliumCultured human vascular endotheliumLeukocyte-vessel wall interactionsIL-1 pretreatmentEndothelial cell damageEndothelial monolayersSites of inflammationIL-1 treatmentHuman umbilical vein endothelial monolayersCertain vascular diseasesPromyelocytic cell line HL-60Polymorphonuclear leukocyte adhesionIL-1 inductionImmune mediatorsHuman endothelial cellsEndothelial adhesivityVascular diseaseBlood leukocytesInterleukin-1Leukocyte cell linesCell line U937