Human vascular smooth muscle cells poorly co-stimulate and actively inhibit allogeneic CD4+ T cell proliferation in vitro.
Murray AG, Libby P, Pober JS. Human vascular smooth muscle cells poorly co-stimulate and actively inhibit allogeneic CD4+ T cell proliferation in vitro. The Journal Of Immunology 1995, 154: 151-61. PMID: 7995934, DOI: 10.4049/jimmunol.154.1.151.Peer-Reviewed Original ResearchConceptsVascular smooth muscle cellsT cell proliferationClass II moleculesHuman vascular smooth muscle cellsMHC class II moleculesT cellsIL-2 productionSmooth muscle cellsEndothelial cellsCell proliferationFunctional MHC class II moleculesII-positive endothelial cellsIL-2-producing cellsMuscle cellsPre-activated T cellsAllogeneic endothelial cellsNitric oxide synthesisInhibition of proliferationVSMC-conditioned mediumAllogeneic CD4CD25 expressionInhibits CD4Immunologic functionVSMC expressionSaphenous vein